Heteroaryl-ureas and their use as glucokinase activators

1. A compound of formula (I)

wherein R 1 is C 3-8 -cycloalkyl optionally substituted with one or more substituents R 3 , R 4 , R 5 and R 6 ;

R 2 is C 3-8 -cycloalkyl optionally substituted with one or more substituents R 30 , R 31 , R 32 and R 33 , and

R 3 , R 4 , R 5 , R 6 , R 30 , R 31 , R 32 and R 33 are independently selected from the group consisting of

halogen, nitro, cyano, hydroxy, oxo, carboxy, —CF 3 ; or

—NR 10 R 11 ; or

C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, aryl, aryl-C 1-6 -alkyl, heteroaryl-C 1-6 -alkyl, C 1-6 -alkoxy, C 3-6 -cycloalkyl-C 1-6 -alkoxy, aryl-C 1-6 -alkoxy, heteroaryl, heteroaryl-C 1-6 -alkoxy, aryloxy, heteroaryloxy, C 1-6 -alkylthio, arylthio, heteroarylthio, C 3-8 -cycloalkylthio, aryl-C 1-6 -alkylthio, heteroaryl-C 1-6 -alkylthio, C 1-6 -alkylsulfenyl, C 3-6 -cycloalkyl-C 1-6 -alkylthio, C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, C 1-6 -alkylthio-C 1-6 -alkyl, carboxy-C 1-6 -alkyloxy, amino-C 1-6 -alkyl, C 1-6 -alkylamino-C 1-6 -alkyl, di-(C 1-6 -alkyl)amino-C 1-6 -alkyl, C 1-6 -alkylsulfamoyl, di(C 1-6 -alkyl)sulfamoyl, C 1-6 -alkylsulfinamoyl or di(C 1-6 -alkyl)sulfinamoyl each of which is optionally substituted with one or more substituents independently selected from R 12 ; or

—C(O)—R 27 , —S(O) 2 —R 27 , —C(O)—NR 13 R 14 , —S(O) 2 —NR 13 R 14 , —C 1-6 -alkyl-C(O)—NR 13 R 14 ; or

two substituents selected from R 3 , R 4 , R 5 and R 6 or R 30 , R 31 , R 32 and R 33 attached to the same or adjacent atoms together form a radical —O—(CH 2 ) 1-3 —O—;

R 10 and R 11 independently represent hydrogen, C 1-6 -alkyl, —C(O)—C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C(O)—C 1-6 -alkyl-C(O)OH, —S(O) 2 —C 1-6 -alkyl, or aryl;

R 27 is C 1-6 -alkyl, C 1-6 -alkoxy, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-8 -cycloalkyl-C 2-6 -alkenyl, aryl, aryl-C 1-6 -alkyl, aryloxy-C 1-6 -alkyl, aryl-C 2-6 -alkenyl, heteroaryl, C 3-8 -heterocyclyl, heteroaryl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, heteroaryloxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, carboxy-C 2-6 -alkenyl, C 1-6 -alkoxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 2-6 -alkenyl, C 1-6 -alkylthio-C 1-6 -alkyl, R 10 HN—C 1-6 -alkyl, R 10 R 11 —N—C 1-6 -alkyl, R 10 R 11 —N—C 2-6 -alkenyl, R 10 R 11 —N—S(O) 2 —C 1-6 -alkyl, R 10 R 11 —N—C(O)—C 1-6 -alkyl, C 1-6 -alkyl-C(O)—NH—C 1-6 -alkyl, aryl-C(O)—NH—C 1-6 -alkyl, heteroaryl-C(O)—NH—C 1-6 -alkyl, C 3-8 -cycloalkyl-C(O)—NH—C 1-6 -alkyl, C 1-6 -alkyl-S(O) 2 —NH—C 1-6 -alkyl, aryl-S(O) 2 —NH—C 1-6 -alkyl, heteroaryl-S(O) 2 —NH—C 1-6 -alkyl, or C 3-8 -cycloalkyl-S(O) 2 —NH—C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 12 ;

R 12 is halogen, cyano, hydroxy, —C(O)—O—C 1-6 -alkyl, carboxy, —CF 3 , C 1-6 -alkyl, C 1-6 -alkoxy, —NR 10 R 11 , —S(O) 2 CH 3 , or —S(O) 2 NH 2 ;

R 13 and R 14 are independently selected from the group consisting of hydrogen, C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, aryl, or heteroaryl, each of which is optionally substituted with one or more substituents independently selected from R 15 ; or R 13 and R 14 together with the nitrogen to which they are attached form a 3 to 8 membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur;

R 15 is halogen, cyano, hydroxy, carboxy, —CF 3 , C 1-6 -alkyl, —S(O) 2 CH 3 , or —S(O) 2 NH 2 ;

A is selected from the group

 and which is optionally substituted with one or more substituents independently selected from R 7 , R 8 ;

R 7 and R 8 are independently selected from

halogen, carboxy, cyano, nitro, hydroxy, —CF 3 , —SCN; or

C 1-6 -alkyl, C 2-6 -alkenyl, C 2-6 -alkynyl, C 1-6 -alkoxy, C 1-6 -alkylthio, C 2-6 -alkenylthio, C 1-6 -alkylamino, C 1-6 -alkylsulfenyl, —C(O)—O—C 1-6 -alkyl, formyl, —C(O)—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-O—C(O)—C 1-6 -alkyl, —NH—C(O)—C 1-6 -alkyl, —C 1-6 -alkoxy-C 1-6 -alkyl, —C 1-6 -alkyl-S—C 1-6 -alkyl, carboxy-C 1-6 -alkyl, or hydroxy-C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

aryl, heteroaryl, aryl-C 1-6 -alkyl, heteroaryl-C 1-6 -alkyl, aryl-C 1-6 -alkoxy, heteroaryl-C 1-6 -alkoxy, aryl-C 1-6 -alkylthio, heteroaryl-C 1-6 -alkylthio, heteroaryl-thio-C 1-6 -alkyl, heteroaryl-oxy-C 1-6 -alkyl, aryloxy, heteroaryloxy, arylthio, heteroarylthio, aryl-C 1-6 -alkylamino, —C(O)-aryl, or —C(O)-heteroaryl, each of which is optionally substituted on the aryl or heteroaryl part with one or more substituents independently selected from R 17 ; or

C 3-8 -cycloalkyl, C 3-8 -cycloalkenyl, C 3-8 -cycloalkylthio, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-8 -cycloalkenyl-C 1-6 -alkyl, C 3-6 -cycloalkyl-C 1-6 -alkoxy, C 3-6 -cycloalkyl-C 1-6 -alkylthio, each of which is optionally substituted on the cycloalkyl part with one or more substituents independently selected from R 18 ; or

C 3-8 -heterocyclyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkylthio, C 3-8 -heterocyclylthio, C 3-8 -heterocyclyl-amino-C 1-6 -alkyl, or —C(O)—C 3-8 -heterocyclyl, each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

—NR 19 R 20 , —C 1-6 -alkyl-NR 19 R 20 , —C 2-6 -alkenyl-NR 19 R 20 , —C 1-6 -alkyl-S—R 21 , —C 1-6 -alkyl-S(O)—R 21 , —C 1-6 -alkyl-S(O) 2 —R 21 , —S(O) 2 —R 21 or —S(O) 2 —NR 19 R 20 , wherein each alkyl part may be substituted with one or more substituents independently selected from R 25 ; or

—C(O)NR 22 R 23 , —C 1-6 -alkyl-C(O)NR 22 R 23 —C 1-6 -alkyl-NH—NR 22 R 23 —C 1-6 -alkyl-NH—C(O)—C 1-6 -alkyl-NR 22 R 23 , each optionally substituted with one or more substituents independently selected from R 26 ; or

R 7 , and R 8 can be taken together to form a C 2-5 -alkylene bridge; the C 2-5 -alkylene bridge is optionally substituted with one or more substituents independently selected from R 16 ;

R 16 , R 17 , and R 18 are independently C 1-6 -alkyl, halogen, nitro, cyano, hydroxy, carboxy, oxo, —CF 3 , carboxy-C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—NR 19 R 20 , —C(O)—O—C 1-6 -alkyl, —C(O)—C 1-6 -alkyl-C(O)—C 1-6 -alkyl, —NR 19 R 20 , —NHS(O) 2 C 1-6 -alkyl, —C(O)NR 19 R 20 , —S(O) 2 C 1-6 -alkyl, or —S(O) 2 NR 19 R 20 ;

R 19 and R 20 independently represent hydrogen, C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, aryl, heteroaryl, C 3-8 -heterocyclyl, aryl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-NR 22 R 23 , or —S(O) 2 —C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 24 , or R 19 and R 20 together with the nitrogen to which they are attached form a 3 to 8 membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 ;

R 21 is selected from

C 1-6 -alkyl, C 2-6 -alkenyl, carboxy-C 1-6 -alkyl, C 1-6 -alkylamino-C 1-6 -alkyl or hydroxy-C 1-6 -alkyl, —C 1-6 -alkyl-NR 22 R 23 ; or

aryl, heteroaryl, aryl-C 1-6 -alkyl, or heteroaryl-C 1-6 -alkyl, wherein the aryl or heteroaryl part is optionally substituted with one or more substituents independently selected from R 24 ; or

C 3-8 -cycloalkyl, C 3-8 -cycloalkenyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-8 -cycloalkenyl-C 1-6 -alkyl;

R 22 and R 23 are independently selected from hydrogen, C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-S(O) 2 —C 1-6 -alkyl, C 3-8 -cycloalkyl, aryl, or heteroaryl; or R 22 and R 23 together with the nitrogen to which they are attached form a 3 to 8 membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 ;

R 24 is halogen, nitro, cyano, hydroxy, carboxy, oxo, —CF 3 , C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C(O)—C 1-6 -alkyl, —C(O)—C 3-8 -cycloalkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)—C 3-8 -heterocyclyl —C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, aryl, heteroaryl, aryl-C 1-6 -alkyl, heteroaryl-C 1-6 -alkyl, C 3-8 -cycloalkyl, C 3-8 -heterocyclyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—C 3-8 -heterocyclyl, —C(O)—O—C 1-6 -alkyl-aryl, —NH—S(O) 2 R 28 , or —S(O) 2 R 28 , wherein each cyclic moiety is optionally substituted with one or more substituents independently selected from R 29 ;

R 25 and R 26 are independently C 1-6 -alkyl, halogen, nitro, cyano, hydroxy, —C(O)—O—C 1-6 -alkyl, carboxy, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —CF 3 , —S(O) 2 CH 3 , or —S(O) 2 NH 2 ;

R 28 is C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, C 3-8 -cycloalkyl, aryl, aryl-C 1-6 -alkyl, heteroaryl optionally substituted with C 1-6 -alkyl, —NH 2 , or —N(CH 3 ) 2 ;

R 29 is halogen, nitro, cyano, hydroxy, carboxy, oxo, —CF 3 , C 1-6 -alkyl, or C 1-6 -alkoxy;

as well as any salt hereof with a pharmaceutically acceptable acid or base, or any optical isomer or mixture of optical isomers, racemic mixture, or tautomeric form thereof.

2. A compound according to claim 1 , wherein R 1 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, bicyclo[3.2.1]octyl, bicyclo[2.2.1]heptyl, norpinyl, norbonyl, or norcaryl, each of which is optionally substituted with one or more substituents R 3 , R 4 , R 5 and R 6 .

3. A compound according to claim 2 , wherein R 1 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, cycloheptyl, bicyclo[3.2.1]octyl, or bicyclo[2.2.1]heptyl, each of which is optionally substituted with one or more substituents R 3 , R 4 , R 5 and R 6 .

4. A compound according to claim 3 , wherein R 1 is cyclopentyl, cyclohexyl, cycloheptyl, or bicyclo[2.2.1]heptyl, each of which is optionally substituted with one or more substituents R 3 , R 4 , R 5 and R 6 .

5. A compound according to claim 4 , wherein R 1 is selected from

6. A compound according to claim 5 , wherein R 1 is selected from

7. A compound according to claim 6 , wherein R 1 is selected from

8. A compound according to claim 7 , wherein R 1 is selected from

9. A compound according to claim 8 , wherein R 1 is selected from

10. A compound according to claim 9 , wherein R 1 is

11. A compound according to claim 9 , wherein R 1 is

12. A compound according to claim 1 , wherein R 2 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, bicyclo[3.2.1]octyl, bicyclo[2.2.1]heptyl, norpinyl, norbonyl, or norcaryl, each of which is optionally substituted with one or more substituents R 30 , R 31 , R 32 and R 33 .

13. A compound according to claim 12 , wherein R 2 is cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, bicyclo[3.2.1]octyl, or bicyclo[2.2.1]heptyl, each of which is optionally substituted with one or more substituents R 30 , R 31 , R 32 and R 33 .

14. A compound according to claim 13 , wherein R 2 is cyclopentyl, cyclohexyl, or bicyclo[2.2.1]heptyl, each of which is optionally substituted with one or more substituents R 30 , R 31 , R 32 and R 33 .

15. A compound according to claim 14 , wherein R 2 is selected from

16. A compound according to claim 15 , wherein R 2 is selected from

17. A compound according to claim 16 , wherein R 2 is selected from

18. A compound according to claim 17 , wherein R 2 is selected from

19. A compound according to claim 18 , wherein R 2 is selected from

20. A compound according to claim 19 , wherein R 2 is

21. A compound according to claim 19 , wherein R 2 is

22. A compound according to claim 1 , wherein R 1 and R 2 are both cyclohexyl.

23. A compound according to claim 1 , wherein R 3 , R 4 , R 5 , R 6 , R 30 , R 31 , R 32 and R 33 are independently selected from the group consisting of

halogen, oxo, cyano, hydroxy, carboxy, —CF 3 ; or

—NR 10 R 11 ; or

C 1-6 -alkyl, C 2-6 -alkenyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, aryl, aryl-C 1-6 -alkyl, C 1-6 -alkoxy, C 3-6 -cycloalkyl-C 1-6 -alkoxy, aryl-C 1-6 -alkoxy, C 1-6 -alkylthio, arylthio, —C(O)—O—C 1-6 -alkyl, or C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 12 ; or

—C(O)—R 27 , —S(O) 2 —R 27 , —C(O)—NR 13 R 14 , —S(O) 2 —NR 13 R 14 , —C 1-6 -alkyl-C(O)—NR 13 R 14 ; or

two substituents selected from R 3 , R 4 , R 5 and R 6 or R 30 , R 31 , R 32 and R 33 attached to the same or adjacent atoms together form a radical —O—(CH 2 ) 1-3 —O—.

24. A compound according to claim 23 , wherein R 3 , R 4 , R 5 , R 6 , R 30 , R 31 , R 32 and R 33 are independently selected from the group consisting of

halogen, oxo, —CF 3 ; or

—NR 10 R 11 ; or

C 1-6 -alkyl, C 3-8 -cycloalkyl, C 1-6 -alkoxy, C 1-6 -alkylthio, aryl, aryl-C 1-6 -alkyl, arylthio, —C(O)—O—C 1-6 -alkyl, or C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 12 ; or

—C(O)—R 27 , —S(O) 2 —NR 13 R 14 or —S(O) 2 —R 27 ; or

two substituents selected from R 3 , R 4 , R 5 and R 6 or R 30 , R 31 , R 32 and R 33 attached to the same or adjacent atoms together form a radical —O—(CH 2 ) 1-3 —O—.

25. A compound according to claim 24 , wherein R 3 , R 4 , R 5 , R 6 , R 30 , R 31 , R 32 and R 33 are independently selected from the group consisting of

halogen, —CF 3 ; or

methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, naphtyl, benzyl, phenyl-ethyl, methoxy, ethoxy, propoxy, phenylthio, —C(O)—O—CH 3 , or —C(O)—O—CH 2 CH 3 , each of which is optionally substituted with one or more substituents independently selected from R 12 ; or

—C(O)—R 27 , —S(O) 2 —NR 13 R 14 or —S(O) 2 —R 27 ; or

two substituents selected from R 3 , R 4 , R 5 and R 6 or R 30 , R 31 , R 32 and R 33 attached to the same or adjacent atoms together form a radical —O—(CH 2 ) 1-3 —O—.

26. A compound according to claim 25 , wherein R 3 , R 4 , R 5 , R 6 , R 30 , R 31 , R 32 and R 33 are independently selected from the group consisting of

halogen, —CF 3 ; or

methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, phenyl, naphtyl, benzyl, phenyl-ethyl, methoxy, ethoxy, propoxy, phenylthio, —C(O)—O—CH 3 , or —C(O)—O—CH 2 CH 3 , each of which is optionally substituted with one or more substituents independently selected from R 12 ; or

—C(O)—R 27 , —S(O) 2 —NR 13 R 14 or —S(O) 2 —R 27 .

27. A compound according to claim 26 , wherein R 3 , R 4 , R 5 , R 6 , R 30 , R 31 , R 32 and R 33 are independently selected from the group consisting of F, Cl, —CF 3 , methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, methoxy, ethoxy, propoxy, —C(O)—R 27 , —S(O) 2 —NR 13 R 14 or —S(O) 2 —R 27 .

28. A compound according to claim 24 , wherein R 3 , R 4 , R 5 , R 6 , R 30 , R 31 , R 32 and R 33 are independently selected from C 1-6 -alkyl, C 1-6 -alkoxy, —S(O) 2 —R 27 or —C(O)—R 27 .

29. A compound according to claim 1 , wherein R 10 and R 11 independently represent hydrogen, methyl, ethyl, propyl, —C(O)—CH 3 , —C(O)—CH 2 CH 3 , —CH 2 C(O)OH, —CH 2 CH 2 C(O)OH, —C(O)—CH 2 —C(O)OH, —C(O)—CH 2 CH 2 —C(O)OH, —S(O) 2 CH 3 , or phenyl.

30. A compound according to claim 29 , wherein R 10 and R 11 independently represent hydrogen, methyl, ethyl, —C(O)—CH 3 , —CH 2 C(O)OH, —C(O)—CH 2 —C(O)OH, —S(O) 2 CH 3 , or phenyl.

31. A compound according to claim 30 , wherein R 10 and R 11 independently represent hydrogen, methyl, ethyl, or phenyl.

32. A compound according to claim 1 , wherein R 27 is C 1-6 -alkyl, C 1-6 -alkoxy, C 2-6 -alkenyl, C 2-6 -alkynyl, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, aryl, aryl-C 1-6 -alkyl, aryl-C 2-6 -alkenyl, heteroaryl, heteroaryl-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, C 1-6 -alkylthio-C 1-6 -alkyl, R 10 HN—C 1-6 -alkyl, R 10 R 11 N—C 1-6 -alkyl, R 10 R 11 N—S(O) 2 —C 1-6 -alkyl, or R 10 R 11 N—C(O)—C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 12 .

33. A compound according to claim 32 , wherein R 27 is C 1-6 -alkyl, C 1-6 -alkoxy, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, aryl-C 2-6 -alkenyl, aryl, heteroaryl, heteroaryl-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, R 10 HN—C 1-6 -alkyl, R 10 R 11 N—C 1-6 -alkyl, R 10 R 11 N—S(O) 2 —C 1-6 -alkyl, or R 10 R 11 N—C(O)—C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 12 .

34. A compound according to claim 33 , wherein R 27 is C 1-6 -alkyl, C 1-6 -alkoxy, C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, aryl, heteroaryl-C 1-6 -alkyl, aryl-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, or heteroaryl, each of which is optionally substituted with one or more substituents independently selected from R 12 .

35. A compound according to claim 34 , wherein R 27 is methyl, ethyl, propyl, n-butyl, isobutyl, 1,1,1-trifluoroethyl, cyclopropyl, cyclopentyl, cyclopropylmethyl, phenyl, pyridyl, thiophene, imidazole, or thiazole, each of which is optionally substituted with one or more substituents independently selected from R 12 .

36. A compound according to claim 35 , wherein R 27 is methyl, ethyl, propyl, n-butyl, isobutyl, 1,1,1-trifluoroethyl, cyclopropyl, cyclopentyl, cyclopropylmethyl, phenyl, or pyridyl, thiophene, imidazole, or thiazole.

37. A compound according to claim 1 , wherein R 12 is halogen, cyano, hydroxy, carboxy, —CF 3 , or C 1-6 -alkyl.

38. A compound according to claim 37 , wherein R 12 is halogen, cyano, hydroxy, carboxy, —CF 3 , methoxy, methyl, ethyl or propyl.

39. A compound according to claim 38 , wherein R 12 is halogen, carboxy, methyl, ethyl or propyl.

40. A compound according to claim 1 , wherein R 13 and R 14 are independently selected from the group consisting of hydrogen, C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, phenyl, or naphtyl, each of which is optionally substituted with one or more substituents independently selected from R 15 ; or R 13 and R 14 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur.

41. A compound according to claim 40 , wherein R 13 and R 14 are independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, hydroxy-methyl, hydroxy-ethyl, carboxy-methyl, carboxy-ethyl, phenyl, or naphtyl, each of which is optionally substituted with one or more substituents independently selected from R 15 ; or R 13 and R 14 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur.

42. A compound according to claim 41 , wherein R 13 and R 14 are independently selected from the group consisting of hydrogen, methyl, ethyl, propyl, or phenyl, each of which is optionally substituted with one or more substituents independently selected from R 15 .

43. A compound according to claim 1 , wherein R 15 is halogen, cyano, hydroxy, carboxy, —CF 3 , methyl, ethyl, or propyl.

44. A compound according to claim 43 , wherein R 15 is halogen, hydroxy, carboxy, —CF 3 , methyl, or ethyl.

45. A compound according to claim 1 , wherein A is

46. A compound according to claim 45 , wherein A is

47. A compound according to claim 1 , wherein R 7 , R 8 are independently selected from

halogen, carboxy, cyano, nitro, hydroxy, —CF 3 , —SCN; or

C 1-6 -alkyl, C 2-6 -alkenyl, C 1-6 -alkoxy, C 1-6 -alkylthio, C 1-6 -alkylamino, C 1-6 -alkylsulfenyl, —C(O)—O—C 1-6 -alkyl, —C(O)—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-O—C(O)—C 1-6 -alkyl, —NH—C(O)—C 1-6 -alkyl, —C 1-6 -alkoxy-C 1-6 -alkyl, —C 1-6 -alkyl-S—C 1-6 -alkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-6 -cycloalkyl-C 1-6 -alkoxy, C 3-6 -cycloalkyl-C 1-6 -alkylthio each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

aryl, heteroaryl, aryl-C 1-6 -alkyl, heteroaryl-C 1-6 -alkyl, aryl-C 1-6 -alkoxy, heteroaryl-C 1-6 -alkoxy, heteroaryl-thio-C 1-6 -alkyl, aryloxy, heteroaryloxy, heteroarylthio, each of which is optionally substituted on the aryl or heteroaryl part with one or more substituents independently selected from R 17 ; or

C 3-8 -cycloalkyl, C 3-8 -cycloalkenyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-8 -cycloalkenyl-C 1-6 -alkyl, each of which is optionally substituted on the cycloalkyl part with one or more substituents independently selected from R 18 ; or

C 3-8 -heterocyclyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, C 3-8 -heterocyclylthio, or —C(O)—C 3-8 -heterocyclyl, each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

—NR 19 R 20 , —C 1-6 -alkyl-NR 19 R 20 , —C 1-6 -alkyl-S—R 21 , —C 1-6 -alkyl-S(O)—R 21 , —C 1-6 -alkyl-S(O) 2 —R 21 , —S(O) 2 —R 21 or —S(O) 2 —NR 19 R 20 , wherein each alkyl part may be substituted with one or more substituents independently selected from R 25 ; or

—C(O)NR 22 R 23 , —C 1-6 -alkyl-C(O)NR 22 R 23 optionally substituted with one or more substituents independently selected from R 26 ; or

R 7 R 8 can be taken together to form a C 2-5 -alkylene bridge.

48. A compound according to claim 47 , wherein R 7 R 8 are independently selected from

halogen, carboxy, cyano, or —CF 3 ; or

C 1-6 -alkyl, C 2-6 -alkenyl, C 1-6 -alkoxy, C 1-6 -alkylthio, —C(O)—O—C 1-6 -alkyl, —C(O)—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-O—C(O)—C 1-6 -alkyl, —C 1-6 -alkoxy-C 1-6 -alkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

aryl, heteroaryl, aryl-C 1-6 -alkyl, heteroaryl-C 1-6 -alkyl, each of which is optionally substituted on the aryl or heteroaryl part with one or more substituents independently selected from R 17 ; or

C 3-8 -cycloalkyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, each of which is optionally substituted on the cycloalkyl part with one or more substituents independently selected from R 18 ; or

C 3-8 -heterocyclyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, or —C(O)—C 3-8 -heterocyclyl, each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

—NR 19 R 20 , —C 1-6 -alkyl-NR 19 R 20 , —S(O) 2 —R 21 or —S(O) 2 —NR 19 R 20 , wherein each alkyl part may be substituted with one or more substituents independently selected from R 25 ; or

—C(O)NR 22 R 23 , —C 1-6 -alkyl-C(O)NR 22 R 23 optionally substituted with one or more substituents independently selected from R 26 ; or

R 7 and R 8 and R 9 can be taken together to form a C 2-5 -alkylene bridge.

49. A compound according to claim 48 , wherein R 7 and R 8 are independently selected from

halogen, carboxy or —CF 3 ; or

C 1-6 -alkyl, C 1-6 -alkoxy, C 1-6 -alkylthio, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-O—C(O)—C 1-6 -alkyl or —C(O)—O—C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

phenyl, benzyl, or heteroarylthio, wherein heteroaryl is pyridyl or imidazolyl, and wherein each aryl or heteroaryl is optionally substituted on the aryl or heteroaryl part with one or more substituents independently selected from R 17 ; or

cyclopropyl, cyclobutyl, cyclopentyl, or cyclohexyl, each of which is optionally substituted on the cycloalkyl part with one or more substituents independently selected from R 18 ; or

pyrrolidinyl, piperidyl, piperazinyl, or morpholinyl, each of which is optionally substituted with one or more substituents independently selected from R 16 ; or

—C(O)NR 22 R 23 —S(O) 2 —R 21 or —S(O) 2 —NR 19 R 20 ; or

R 7 R 8 can be taken together to form a C 2-5 -alkylene bridge.

50. A compound according to claim 49 , wherein R 7 R 8 are independently selected from halogen, carboxy, —CF 3 , —S—CH 3 , —S—CH 2 CH 3 , —S—CH 2 CH 2 CH 3 , methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, methoxy, ethoxy, —CH 2 —C(O)—O—CH 3 , —CH 2 —C(O)—O—CH 2 CH 3 , —CH 2 CH 2 —C(O)—O—CH 3 , —CH 2 CH 2 —C(O)—O—CH 2 CH 3 , —CH 2 —O—C(O)—CH 3 , —CH 2 —O—C(O)—CH 2 CH 3 , —CH 2 CH 2 —O—C(O)—CH 3 , —CH 2 CH 2 —O—C(O)—CH 2 CH 3 , —C(O)—O—CH 3 , —C(O)—O—CH 2 CH 3 , each of which is optionally substituted with one or more substituents independently selected from R 16 ; or heteroarylthio, wherein heteroaryl is pyridyl or imidazolyl, each optionally substituted on the heteroaryl part with one or more substituents independently selected from R 17 , or pyrrolidinyl, piperidyl, piperazinyl, or morpholinyl, each of which is optionally substituted with one or more substituents independently selected from R 16 , or —S(O) 2 —R 21 .

51. A compound according to claim 50 , wherein R 7 R 8 and are independently selected from Cl, F, Br, —CF 3 , —S—CH 3 , —S—CH 2 CH 3 , —S—CH 2 CH 2 CH 3 , methyl, ethyl, methoxy, ethoxy, —CH 2 —C(O)—O—CH 2 CH 3 , —C(O)—O—CH 3 , or —C(O)—O—CH 2 CH 3 , each of which is optionally substituted with one or more substituents independently selected from R 16 ; or heteroarylthio, wherein heteroaryl is pyridyl or imidazolyl, each optionally substituted on the heteroaryl part with one or more substituents independently selected from R 17 , or pyrrolidinyl, piperidyl, piperazinyl, or morpholinyl, each of which is optionally substituted with one or more substituents independently selected from R 16 .

52. A compound according to claim 1 , wherein R 16 , R 17 , and R 18 are independently C 1-6 -alkyl, halogen, hydroxy, oxo, carboxy, —CF 3 , carboxy-C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, —NR 19 R 20 , —C(O)NR 19 R 20 or —S(O) 2 —C 1-6 -alkyl.

53. A compound according to claim 52 , wherein R 16 , R 17 , and R 18 are independently methyl, ethyl, propyl, halogen, hydroxy, oxo, carboxy, —CF 3 , carboxy-methyl, carboxy-ethyl, carboxy-propyl, hydroxy-methyl, hydroxy-ethyl, hydroxy-propyl, —CH 2 —C(O)—O—CH 3 , —CH 2 —C(O)—O—CH 2 CH 3 , —CH 2 CH 2 —C(O)—O—CH 3 , —CH 2 CH 2 —C(O)—O—CH 2 CH 3 , —C(O)—O—CH 3 , —C(O)—O—CH 2 CH 3 , —C(O)—O—CH 2 CH 2 CH 3 , or —S(O) 2 CH 3 .

54. A compound according to claim 53 , wherein R 16 , R 17 , and R 18 are independently methyl, ethyl, propyl, halogen, oxo, carboxy, carboxy-methyl, carboxy-ethyl, carboxy-propyl, hydroxy-methyl, hydroxy-ethyl, hydroxy-propyl, —CH 2 —C(O)—O—CH 3 , —CH 2 —C(O)—O—CH 2 CH 3 , —CH 2 CH 2 —C(O)—O—CH 3 , —CH 2 CH 2 —C(O)—O—CH 2 CH 3 , —C(O)—O—CH 3 , —C(O)—O—CH 2 CH 3 , —C(O)—O—CH 2 CH 2 CH 3 , or —S(O) 2 CH 3 .

55. A compound according to claim 52 , wherein R 16 , R 17 , and R 18 are independently C 1-6 -alkyl, carboxy, —NR 19 R 20 , —C(O)—O—C 1-6 -alkyl or —C(O)NR 19 R 20 .

56. A compound according to claim 1 , wherein R 19 and R 20 independently represent hydrogen, C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, phenyl, naphtyl, C 3-8 -heterocyclyl, phenyl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-NR 22 R 23 or —S(O) 2 —C 1-6 -alkyl, each of which is optionally substituted with one or more substituents independently selected from R 24 ; or R 19 and R 20 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 .

57. A compound according to claim 56 , wherein R 19 and R 20 independently represent hydrogen, methyl, ethyl, propyl, carboxy-methyl, carboxy-ethyl, carboxy-propyl, hydroxy-methyl, hydroxy-ethyl, hydroxy-propyl, phenyl, phenyl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-NR 22 R 23 , or naphtyl, or R 19 and R 20 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 .

58. A compound according to claim 56 , wherein R 19 and R 20 independently represent hydrogen, C 1-6 -alkyl, or R 19 and R 20 together with the nitrogen to which they are attached form a 3- to8-membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 .

59. A compound according to claim 58 , wherein R 19 and R 20 independently represent hydrogen,methyl, ethyl, or propyl, or R 19 and R 20 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, wherein the heterocyclic ring is pyrrolidyl, piperidyl, piperazinyl, homopiperazinyl, or morpholinyl, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 .

60. A compound according to claim 1 , wherein R 21 is selected from

C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C 1-6 -alkyl-NR 22 R 23 or hydroxy-C 1-6 -alkyl; or

phenyl, naphtyl, or phenyl-C 1-6 -alkyl, wherein the aryl part is optionally substituted with one or more substituents independently selected from R 24 ; or

C 3-8 -cycloalkyl, or C 3-8 -cycloalkyl-C 1-6 -alkyl.

61. A compound according to claim 60 , wherein R 21 is selected from

methyl, ethyl, propyl, carboxy-methyl, carboxy-ethyl, carboxy-propyl, hydroxy-methyl, hydroxy-ethyl, hydroxy-propyl; or

phenyl, naphtyl, or phenyl-C 1-6 -alkyl, wherein the aryl part is optionally substituted with one or more substituents independently selected from R 24 ; or

C 3-8 -cycloalkyl, or C 3-8 -cycloalkyl-C 1-6 -alkyl.

62. A compound according to claim 61 , wherein R 21 is selected from

methyl, ethyl, carboxy-methyl, carboxy-ethyl, carboxy-propyl; or

phenyl, naphtyl, or phenyl-C 1-6 -alkyl, wherein the aryl part is optionally substituted with one or more substituents independently selected from R 24 .

63. A compound according to claim 1 , wherein R 22 and R 23 are independently selected from hydrogen, C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, C 3-8 -cycloalkyl, phenyl, naphtyl, or R 22 and R 23 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, the heterocyclic ring optionally containing one or two further heteroatoms selected from nitrogen, oxygen and sulphur, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 .

64. A compound according to claim 63 , wherein R 22 and R 23 are independently selected from hydrogen, methyl, ethyl, propyl, butyl, carboxymethyl, carboxyethyl, carboxypropyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, phenyl, naphtyl, or R 22 and R 23 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, wherein the heterocyclic ring is pyrrolidyl, piperidyl, piperazinyl, homopiperazinyl, or morpholinyl, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 .

65. A compound according to claim 64 , wherein R 22 and R 23 together with the nitrogen to which they are attached form a 3- to 8-membered heterocyclic ring with the said nitrogen atom, wherein the heterocyclic ring is pyrrolidyl, piperidyl, piperazinyl, homopiperazinyl, or morpholinyl, the heterocyclic ring is optionally substituted with one or more substituents independently selected from R 24 .

66. A compound according to claim 1 , wherein R 24 is halogen, hydroxy, carboxy, oxo, —CF 3 , C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C(O)—C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, aryl, heteroaryl, aryl-C 1-6 -alkyl, heteroaryl-C 1-6 -alkyl, C 3-8 -cycloalkyl, C 3-8 -heterocyclyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl-aryl, or —S(O) 2 R 28 , wherein aryl is phenyl or naphtyl, and heteroaryl is pyridyl or pyrimidyl, and wherein each cyclic moiety is optionally substituted with one or more substituents independently selected from R 29 .

67. A compound according to claim 66 , wherein R 24 is halogen, hydroxy, carboxy, oxo, —CF 3 , C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C(O)—C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, aryl, heteroaryl, aryl-C 1-6 -alkyl, heteroaryl-C 1-6 -alkyl, C 3-8 -cycloalkyl, C 3-8 -heterocyclyl, C 3-8 -cycloalkyl-C 1-6 -alkyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, or —S(O) 2 R 28 , wherein aryl is phenyl or naphtyl, and heteroaryl is pyridyl or pyrimidyl, and wherein each cyclic moiety is optionally substituted with one or more substituents independently selected from R 29 .

68. A compound according to claim 67 , wherein R 24 is halogen, carboxy, oxo, —CF 3 , C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C(O)—C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, aryl, aryl-C 1-6 -alkyl, C 3-8 -cycloalkyl, C 3-8 -heterocyclyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, or —S(O) 2 R 28 , wherein aryl is phenyl or naphtyl, and wherein each cyclic moiety is optionally substituted with one or more substituents independently selected from R 29 .

69. A compound according to claim 68 , wherein R 24 is carboxy, oxo, C 1-6 -alkyl, carboxy-C 1-6 -alkyl, —C(O)—O—C 1-6 -alkyl, aryl, aryl-C 1-6 -alkyl, C 3-8 -cycloalkyl, C 3-8 -heterocyclyl, C 3-8 -heterocyclyl-C 1-6 -alkyl, or —S(O) 2 R 28 , wherein aryl is phenyl or naphtyl, and wherein each Cyclic moiety is optionally substituted with one or more substituents independently selected from R 29 .

70. A compound according to claim 1 , wherein R 25 and R 26 are independently C 1-6 -alkyl, halogen, hydroxy, carboxy, or —CF 3 .

71. A compound according to claim 70 , wherein R 25 and R 26 are independently methyl, ethyl, propyl, halogen, hydroxy, carboxy, or —CF 3 .

72. A compound according to claim 1 , wherein R 28 is C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, phenyl, phenyl-C 1-6 -alkyl, heteroaryl optionally substituted with C 1-6 -alkyl or —N(CH 3 ) 2 , wherein heteroaryl is imidazolyl, pyridyl or pyrimidyl.

73. A compound according to claim 72 , wherein R 28 is C 1-6 -alkyl, —C 1-6 -alkyl-C(O)—O—C 1-6 -alkyl, or —N(CH 3 ) 2 .

74. A compound according to claim 1 , wherein R 29 is halogen, carboxy, —CF 3 , C 1-6 -alkyl, or C 1-6 -alkoxy.