Methods for manipulating satiety
Disclosed is a method of manipulating the rate of upper gastrointestinal transit of a substance in a mammal. Also disclosed are methods of manipulating satiety and post-prandial visceral blood flow. A method of treating visceral pain or visceral hypersensitivity in a human subject is also described. A method for prolonging the residence time of an orally or enterally administered substance by promoting its dissolution, bioavailability and/or absorption in the small intestine is also described. These methods are related to a method of transmitting to and replicating at a second location in the central nervous system a serotonergic neural signal originating at a first location in the proximal or distal gut of a mammal and/or a method of transmitting to and replicating at a second location in the upper gastrointestinal tract a serotonergic neural signal originating at a first location in the proximal or distal gut.
1. A method for treating obesity in a mammalian subject comprising administering a peptide that binds to the Y1, Y2, Y4 or Y5 PYY receptor to said mammal.
2. The method of claim 1 wherein said mammalian subject is a human.
3. The method of claim 2 wherein said peptide is administered mucosally.
4. The method of claim 3 wherein said peptide is administered by an oral delivery route.
5. The method of claim 2 wherein said peptide is administered parenterally.
6. The method of claim 1 wherein said peptide is comprised of the amino acid sequence as disclosed by SEQ ID NO:1.
7. A method for treating obesity in a human subject comprising parenterally administering to said human a peptide that binds to the Y1, Y2, Y4 or Y5 PYY receptor at a dose of from about 0.5 to about 500 picomoles/kg weight of the subject wherein said peptide is comprised of the amino acid sequence as disclosed by SEQ ID NO:1.
8. A method of inducing satiety in a mammalian subject comprising administering a peptide that binds to the Y1, Y2, Y4 or Y5 PYY receptor to said mammalian subject.
9. The method of claim 8 wherein said subject is a human.
10. The method of claim 9 wherein said peptide is administered mucosally.
11. The method of claim 10 wherein the peptide is administered orally.
12. The method of claim 8 wherein the peptide is administered parenterally.
13. The method of claim 8 wherein said peptide is comprised of the amino acid sequence as disclosed by SEQ ID NO:1.
14. A method for inducing satiety in a human subject comprising parenterally administering to said subject a peptide that binds to the Y1, Y2, Y4 or Y5 PYY receptor at a dose of from about 0.5 to about 500 picomoles/kg weight of the subject wherein said peptide is comprised of the amino acid sequence as disclosed by SEQ ID NO:1.