Granted Patent
B2
US 7,501,444 · App. 11/457,788 · Granted Mar 10, 2009
Prenylation inhibitors and methods of their synthesis and use
Assignee:
PPD Discovery, Inc.
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Abstract
The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same.
Claims (6)
1. A compound having a formula selected from the group consisting of:
and a pharmaceutically-acceptable salt thereof,
wherein R is a halogenated phenyl.
2. The compound of claim 1 , wherein R is 3,4-dichlorophenyl.
3. The compound of claim 1 , wherein R is 3-chlorophenyl.
4. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically-acceptable carrier.
Assignments (6)
RELEASE OF SECURITY INTEREST
Recorded Jan 15, 2021
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
To: JAGUAR HOLDING COMPANY I; JAGUAR HOLDING COMPANY II; PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC
Reel/Frame 054931/0201 →
RELEASE OF SECURITY INTEREST
Recorded Sep 2, 2015
From: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS ADMINISTRATIVE AGENT
To: PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC; PPD DEVELOPMENT, L.P.; PHARMACO INVESTEMENTS, INC.; X-CHEM, INC.
Reel/Frame 036481/0051 →
SECURITY AGREEMENT
Recorded Sep 2, 2015
From: PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC; PPD DEVELOPMENT, L.P.; PHARMACO INVESTEMENTS, INC.; X-CHEM, INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS COLLATERAL AGENT
Reel/Frame 036528/0004 →
SECURITY AGREEMENT
Recorded Dec 6, 2011
From: PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.; PPD DEVELOPMENT, LP; PHARMACO INVESTMENTS INC. AND DUKE UNIVERSITY; PHARMACO INVESTMENTS INC.
To: CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, AS ADMINISTRATIVE AGENT
Reel/Frame 027334/0106 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 16, 2011
From: PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
To: PHARMACO INVESTMENTS, INC.
Reel/Frame 027237/0001 →
MERGER
Recorded Feb 3, 2009
From: PPD DISCOVERY, INC.
To: PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
Reel/Frame 022191/0690 →
Continuity (5)