Granted Patent
B2
US 7,772,199 · App. 11/458,365 · Granted Aug 10, 2010
Forms of 5-azacytidine
Assignee:
Celgene Corporation
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Abstract
The invention provides novel polymorphic and pseudopolymorphic crystalline forms of 5-azacytidine, along with methods for preparing said forms, wherein 5-azacytidine is represented by the formula: The invention also includes pharmaceutical compositions comprising said forms.
Claims (2)
1. Amorphous solid 5-azacytidine, prepared by a method comprising adding solid 5-azacytidine to a solvent selected from propylene glycol, polyethylene glycol, and DMSO; allowing equilibration to occur; and recovering 5-azacytidine therefrom.
2. A pharmaceutical composition comprising the amorphous 5-azacytidine of claim 1 and a pharmaceutically acceptable excipient, diluent, or carrier.
Assignments (6)
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY PREVIOUSLY RECORDED ON REEL 022773 FRAME 0873. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER.
Recorded Jul 27, 2010
From: PHARMION CORPORATION
To: PHARMION LLC
Reel/Frame 024741/0662 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 27, 2010
From: ASH STEVENS, INC.
To: CELGENE INTERNATIONAL SARL
Reel/Frame 024741/0679 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 27, 2010
From: CELGENE INTERNATIONAL SARL
To: PHARMION LLC
Reel/Frame 024741/0688 →
MERGER
Recorded Jun 4, 2009
From: PHARMION CORPORATION
To: CELGENE CORPORATION
Reel/Frame 022773/0873 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 7, 2006
From: IONESCU, DUMITRU; BLUMBERGS, PETER
To: ASH STEVENS, INC.
Reel/Frame 018064/0352 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Aug 7, 2006
From: SILVEY, GARY L
To: PHARMION CORPORATION
Reel/Frame 018064/0399 →
Continuity (3)