Nicotinamide derivatives useful as p38 inhibitors
Compounds of formula (I): are inhibitors of p38 kinase and are useful in the treatment of conditions or disease states mediated by p38 kinase activity or mediated by cytokines produced by the activity of p38.
1. A compound of the formula:
wherein
W is halogen;
Z is halogen;
R 1 is 2,2-dimethylpropyl;
R 2 is selected from hydrogen, C 1-6 alkyl and —(CH 2 ) q —C 3-7 cycloalkyl optionally substituted by one or more C 1-6 alkyl groups;
n is selected from 0, 1 and 2; and
q is selected from 0, 1 and 2.
2. The compound according to claim 1 wherein R 2 is hydrogen.
3. The compound according to claim 1 wherein R 2 is hydrogen, and n is 0.
4. The compound according to claim 3 wherein W is chlorine.
5. The compound according to claim 1 wherein n is 0.
6. The compound according to claim 1 wherein n is 0, and W is chlorine.
7. The compound according to claim 1 wherein W is chlorine.
8. The compound according to claim 1 wherein R 2 is C 1-6 alkyl.
9. The compound according to claim 1 wherein R 2 is —(CH 2 ) q —C 3-7 cycloalkyl optionally substituted by one or more C 1-6 alkyl groups.
10. The compound which is 6-Chloro-N-(2,2-dimethylpropyl)-3-pyridinecarboxamide.