Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on muscarinic receptor modulation, such as via inhibition of acetylcholine esterase (AChE) activity, alone or in combination with another neurogenic agent to stimulate or activate the formation of new nerve cells.
1. A method of treating a nervous system disorder related to depression in a subject or patient in need thereof, comprising administering a composition consisting essentially of sabcomeline and an SSRI, wherein the composition is effective to treat the disorder.
2. The method of claim 1 , wherein the SSRI is fluoxetine.