Application of chromium-amino acid complexes in the treatment of diabetes and other diseases
Compositions comprising chromium (III) 1:3 complexes comprising amino acids and methods of use thereof are provided.
1. A chromium (III) complex comprising D-amino acids.
2. The complex of claim 1 , further comprising L-amino acids.
3. The complex of claim 1 , wherein said amino acid is selected from the group consisting of phenylalanine, proline, cysteine, isoleucine, and methionine.
4. The complex of claim 1 , wherein said amino acid is D-phenylalanine.
5. The complex of claim 4 of the formula:
6. A composition comprising the complex of claim 1 and a pharmaceutically acceptable carrier.
7. The composition of claim 6 , further comprising at least one agent for treating diabetes.
8. The composition of claim 6 , further comprising at least one agent for lowering cholesterol.
9. A method of forming the complex of claim 1 comprising heating a mixture of a chromium (III) salt with three molar equivalents of said amino acids.
10. A method for the treatment of diabetes in a patient having diabetes, said method comprising administering an effective amount of the composition of claim 6 .
11. A method for the treatment of insulin resistance syndrome in a patient having insulin resistance syndrome, said method comprising administering an effective amount of the composition of claim 6 .
12. A method in preventing the onset of diabetes in a patient, said method comprising administering an effective amount of the composition of claim 6 .
13. A method for decreasing plasma cholesterol levels in a patient in need thereof, said method comprising administering an effective amount of the composition of claim 6 .
14. A chromium (III) complex comprising a derivative of D-phenylalanine.
15. The complex of claim 14 , wherein said derivative of D-phenylalanine comprises substituents on the phenyl ring.
16. The complex of claim 14 , wherein said derivative of D-phenylalanine is nateglinide.
17. A composition comprising a chromium (III) complex comprising amino acids, a pharmaceutically acceptable carrier, and at least one agent for lowering cholesterol.
18. A method for decreasing plasma cholesterol levels in a patient in need thereof, said method comprising administering an effective amount of the composition of claim 17 .
19. The method of claim 18 , wherein said amino acids are L- or D,L-amino acids.