Engineered anti-IL-23 antibodies
View Patent ↗Engineered antibodies to human IL-23p19 are provided, as well as uses thereof, e.g. in treatment of inflammatory, autoimmune, and proliferative disorders.
1. A purified monoclonal antibody, or antigen binding fragment thereof, that binds to human IL-23p19 at an epitope comprising residues 133-140 of SEQ ID NO: 29.
2. A purified monoclonal antibody, or antigen binding fragment thereof, that binds to human IL-23p19 at an epitope comprising residues 82-95 and residues 133-140 of SEQ ID NO: 29.
3. A purified monoclonal antibody, or antigen binding fragment thereof, that is able to block the binding of a binding compound to human IL-23p19 in a cross-blocking assay, wherein the binding compound consists of:
a monoclonal antibody, or antigen binding fragment thereof, that binds to human IL-23p19 at an epitope comprising residues 133-140 of SEQ ID NO: 29.
4. A purified monoclonal antibody, or antigen binding fragment thereof, that is able to block the binding of a binding compound to human IL-23p19 in a cross-blocking assay, wherein the binding compound consists of:
a monoclonal antibody, or antigen binding fragment thereof, that binds to human IL-23p19 at an epitope comprising residues 82-95 and residues 133-140 of SEQ ID NO: 29.