Granted Patent
B2
US 7,608,246 · App. 11/516,017 · Granted Oct 27, 2009
Apolipoprotein E as an adjuvant for lipid antigens
Assignee:
The Brigham and Women's Hospital, Inc.
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Abstract
The present invention is directed to pharmaceutical compositions that contain a combination of apolipoprotein E and an antigenic lipid. The compositions may be administered to a subject for the purpose of inducing an immune response against the lipid and in immunization protocols.
Claims (3)
1. A method of inducing the production of antibodies against an antigenic lipid, comprising administering to a subject capable of antibody production a composition comprising:
a) said antigenic lipid; and
b) apolipoprotein E in an amount that, together with said antigenic lipid, is sufficient to induce production of said antibodies.
Assignments (3)
CONFIRMATORY LICENSE
Recorded Apr 14, 2017
From: PARTNERS HEALTHCARE INNOVATION
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 042006/0051 →
CONFIRMATORY LICENSE
Recorded Jun 18, 2009
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022841/0673 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 7, 2008
From: VAN DEN ELZEN, PETER; BRENNER, MICHAEL B.
To: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Reel/Frame 021199/0542 →
Continuity (2)
Provisional Application
6071336400
· Sep 2, 2005