Formulations for topical delivery of bioactive substances and methods for their use
The invention relates to topical delivery of bioactive agents. More particularly, the invention relates to anhydrous formulations for percutaneous absorption. The invention provides formulations that allow efficient topical delivery of high concentrations of bioactive substances for percutaneous absorption. The formulations according to the invention are generally non-irritating to the skin.
1. An anhydrous topical cream delivery formulation for percutaneous absorption consisting essentially of capric/caprylic triglyceride, glycerol, beta hydroxy acid, and one or more diethylene glycol monoethyl ether, dimethyl isosorbide, propylene glycol, oleic acid, epidermal enzymes, ethanol and dimethylsulfoxide.
2. The anhydrous formulation according to claim 1 , wherein the glycerol is present in a concentration of 20%-40%.