Methods of increasing learning rate
The invention relates, in part, to methods of administering electrical or magnetic brain stimulation to increase learning rate.
1. A method for increasing the rate of learning in a subject, the method comprising,
electrically stimulating the striatum in the brain of the subject during an interval of learning in the subject, wherein the interval of learning comprises a reinforcement interval that is a feedback period of learning.
2. The method of claim 1 , wherein the learning comprises formation of a visual-motor association.
3. The method of claim 1 , wherein stimulating the striatum is stimulating the caudate.
4. The method of claim 1 , wherein stimulating the striatum is stimulating the anterior caudate.
5. The method of claim 1 , wherein the stimulation of the striatum comprises deep brain stimulation.
6. The method of claim 5 , wherein the deep brain stimulation comprises high frequency microstimulation.
7. The method of claim 6 , wherein the high frequency microstimulation is at a pulse frequency of about 200 Hz.
8. The method of claim 6 , wherein the high frequency micro stimulation is at a phase length of about 0.2 ms.
9. The method of claim 6 , wherein the high frequency microstimulation is at an interphase interval of about 0.2 ms.
10. The method of claim 6 , wherein the high frequency microstimulation is at an amperage of about 200 μA.
11. The method of claim 6 , wherein the high frequency microstimulation comprises a stimulus train of about 1000 ms.
12. The method of claim 1 , wherein the stimulation of the striatum comprises epidural electrical stimulation.
13. The method of claim 1 , wherein the subject has, has had, or is suspected of having a neurological disease or disorder.
14. The method of claim 13 , wherein the neurological disease or disorder is associated with a deficit in learning.
15. The method of claim 13 , wherein the neurological disease or disorder is a associated with a deficit in the formation of visual-motor associations.
16. The method of claim 13 , wherein the neurological disease or disorder is an associative learning disorder, a brain injury, a neurodegenerative disorder, stroke, epilepsy, autism, or Parkinson's disease.
17. The method of claim 1 , wherein the subject is a primate.
18. The method of claim 1 , wherein the subject is a human.