Calcium carbonate granulation
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
1. A granulation comprising free-flowing particles having sufficient cohesiveness and compactability for compression into pharmaceutical or dietary supplement tablets comprising:
i. a first powdered composition comprising a median particle diameter from about 10 to about 25 μm;
ii. a second powdered composition comprising a median particle diameter from about 0.1 to about 10 μm; and
iii. a binder,
wherein said first powdered composition comprises about 50% or more of said granulation, on a weight basis, and said second powdered composition comprises up to about 50% of said granulation, on a weight basis; and
wherein said granulation has a moisture content of less than about 1% by weight and wherein said first and second powdered compositions each comprise calcium carbonate.
2. The granulation of any of claim 1 wherein said binder comprises maltodextrin.
3. The granulation of claim 1 wherein said first powdered composition has a median particle diameter from about 12 to about 17 μm and said second powdered composition has a median particle diameter from about 1 to about 5 μm.
4. The granulation of claim 1 wherein said first powdered composition has a median particle diameter of about 15 μm and said second powdered composition has a median particle diameter of about 4 μm.
5. A granulation comprising free-flowing particles having sufficient cohesiveness and compactability for compression into pharmaceutical or dietary supplement tablets comprising:
i. a first powdered composition having a median particle diameter from about 10 to about 25 μm;
ii. second powdered composition having a median particle diameter from about 1 to about 10 μm;
iii. a third powdered composition having a median particle diameter from about 0.1 to about 1 μm; and
iv. a binder,
wherein said first powdered composition comprises about 50% or more of said granulation, on a weight basis, said second powdered composition comprises from about 10 to about 50% of said granulation, on a weight basis, and said third powdered composition comprises up to about 20% of said granulation, on a weight basis; and
wherein said granulation has a moisture content of less than about 1% by weight and wherein each of said first, second and third powdered compositions comprises calcium carbonate.
6. The granulation of claim 5 wherein said binder comprises maltodextrin.
7. The granulation of claim 5 wherein said first powdered composition has a median particle diameter from about 12 to about 17 μm; said second powdered composition has a median particle diameter from about 1 to about 5 μm; and said third powdered composition has a median particle diameter from about 0.5 to about 1 μm.
8. The granulation of claim 5 wherein said first powdered composition has a median particle diameter of about 15 μm; said second powdered composition has a median particle diameter of about 10 μm; and said third powdered composition has a median particle diameter of about 0.7 μm.
9. A pharmaceutical or dietary supplement tablet comprising the granulation of claim 1 or 5 .