Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.
1. A compound having the structural formula:
or a pharmaceutically acceptable salt, solvate, or prodrug thereof.
2. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 .
3. The pharmaceutical composition of claim 2 , wherein said composition is suitable for oral, parenteral, or intravenous infusion administration.
4. The pharmaceutical composition of claim 3 , wherein said composition suitable for oral administration comprises a tablet or a capsule.
5. The pharmaceutical composition of claim 2 , wherein said compound of claim 6 is administered in a total daily dose of 0.5 milligram to 400 milligram.
6. The compound of claim 1 , wherein said compound is a mixture of about 90% or more by weight of the (+)-enantiomer and about 10% or less by weight of the (−)-enantiomer.
7. The compound of claim 1 , wherein said compound is a mixture of about 90% or more by weight of the (−)-enantiomer and about 10% or less by weight of the (+)-enantiomer.
8. The compound of claim 1 , wherein said compound is a hydrochloride salt.
9. The compound of claim 8 , wherein said hydrochloride salt is a mixture of about 90% or more by weight of the (+)-enantiomer and about 10% or less by weight of the (−)-enantiomer.
10. The compound of claim 8 , wherein said hydrochloride salt is a mixture of about 90% or more by weight of the (−)-enantiomer and about 10% or less by weight of the (+)-enantiomer.