Disposable chromatography valves and system
Described is a disposable valve that includes an actuation layer operationally linked to a flexible diaphragm; a valving layer operationally linked to the flexible diaphragm; and a connection layer operationally connected to the valving layer; wherein the valving layer and the connection layer have a corresponding plurality of channels passing therethrough, and the channels define at least one fluid flow path, and the flexible diaphragm is movable between a first open position wherein fluid can flow through the fluid flow path, and a second closed position wherein fluid cannot flow through the fluid flow path. Chromatographic systems incorporating a plurality of such valves, optionally integrated into a unitary valve block, are also described.
1. A liquid chromatography system comprising:
a valve comprising:
an actuation layer operationally linked to a flexible diaphragm;
a valving layer operationally linked to the flexible diaphragm; and
a connection layer operationally connected to the valving layer; wherein the valving layer and the connection layer have a corresponding plurality of channels passing therethrough, wherein the channels define at least one fluid flow path, and wherein the flexible diaphragm is movable between a first open position wherein fluid can flow through the fluid flow path, and a second closed position wherein fluid cannot flow through the fluid flow path; the actuation layer, valving layer, and connection layer defining a disposable valve that does not include an actuator, whereby the valve may be disposed of without disposing of the actuator;
operationally linked to a peristaltic pump.
2. The liquid chromatography system as recited in claim 1 , further comprising at least one chromatography column operationally linked to the valve.
3. The liquid chromatography system as recited in claim 2 , further comprising a detector operationally linked to the column.
4. The liquid chromatography system as recited in claim 3 , further comprising a user-programmable controller dimensioned and configured to control operation of the valve, the pump, and the detector.
5. The liquid chromatography system as recited in claim 4 , further comprising a plurality of chromatography columns.
6. The liquid chromatography system as recited in claim 1 , comprising a plurality of valves, each valve comprising an actuation layer operationally linked to a flexible diaphragm; a valving layer operationally linked to the flexible diaphragm; and a connection layer operationally connected to the valving layer; wherein the valving layer and the connection layer have a corresponding plurality of channels passing therethrough, wherein the channels define at least one fluid flow path, and wherein the flexible diaphragm is movable between a first open position wherein fluid can flow through the fluid flow path, and a second closed position wherein fluid cannot flow through the fluid flow path.