Use of Carbamoyl Phosphate Synthetase 1 (Cps) as a Humoral Biomarker For the Diagnosis of Tumour Diseases and Chronic Inflammatory Intestinal Diseases

1 - 3 . (canceled)

4 . The method of claim 9 , wherein said a immunoassay is a sandwich assay.

5 . (canceled)

6 . The method of claim 9 , wherein said tumor disease is selected from the group consisting of carcinomas of the large intestine, liver carcinomas, kidney carcinomas, pancreatic carcinomas, lung carcinomas and breast carcinomas and combinations thereof.

7 - 8 . (canceled)

9 . A method for the diagnosis of a tumor disease, said method comprising:

determining the level of human carbamoyl phosphate synthetase 1 (CPS 1) and/or physiologically occurring fragments that retain human CPS 1 immunoreactivity in a serum or plasma sample of a human patient using, an immunoassay a that uses a first antibody that binds to a first epitope of a first peptide consisting of the sequence of SEQ ID NO:1, and a second antibody that binds to a second epitope of a second peptide consisting of the sequence of SEQ ID NO:2; and

comparing the level of human CPS 1 and/or CPS1 fragments that retain CPS 1 immunoreactivity in said sample with the level in normal individuals, wherein an increased level compared to normal individuals indicates a tumor disease.