Anti-Inflammatory Analgesic External Aqueus Liquid Preparation
An anti-inflammatory analgesic external aqueous liquid preparation that excels in percutaneous absorbability and applicability, and being stable over time. There is provided an anti-inflammatory analgesic external aqueous liquid preparation comprising diclofenac or its salt, a dibasic acid ester, a lower alcohol, and 0.05 to 0.45 wt % of thickening agent.
1 . An anti-inflammatory analgesic external aqueous liquid preparation comprising diclofenac or its salt, a dibasic acid ester, a lower alcohol, and 0.05 to 0.45 wt % of thickening agent.
2 . The anti-inflammatory analgesic external aqueous liquid preparation according to claim 1 , containing 0.1 to 20 wt % of the diclofenac or its salt, 0.5 to 20 wt % of the dibasic acid ester, and 10 to 80 wt % of the lower alcohol.
3 . The anti-inflammatory analgesic external aqueous liquid preparation according to claim 1 or 2 , wherein the salt of diclofenac is diclofenac sodium or diclofenac ammonium.
4 . The anti-inflammatory analgesic external aqueous liquid preparation according to any one of claims 1 to 3 , wherein the dibasic acid ester is diisopropyl adipate, diisopropyl sebacate, or diethyl sebacate.
5 . The anti-inflammatory analgesic external aqueous liquid preparation according to any one of claims 1 to 4 , wherein the lower alcohol is ethyl alcohol and/or isopropyl alcohol.
6 . The anti-inflammatory analgesic external aqueous liquid preparation according to any one of claims 1 to 5 , wherein the thickening agent is hydroxy propyl cellulose and/or hydroxy ethyl cellulose.
7 . The anti-inflammatory analgesic external aqueous liquid preparation according to any one of claims 1 to 6 , wherein the pH is in the range of 5 to 8.5.