Organic polymer particles and process for producing the same, magnetic particles for diagnostics, carboxyl group-containing particles and process for producing the same, and probe-bound particles and process for producing the same
The organic polymer particles comprise a carboxyl group and 2,3-dihydroxypropyl group, and the magnetic particles for diagnostics comprise fine magnetic material particles and a polymer part containing a hydrophilic polymer part and a crosslinked polymer part, a dry coating film obtained from a water dispersion thereof having a contact angle with water of 5° to 60°. The process for producing the carboxyl group-containing particles comprises a step of producing an ester bond by reacting a hydroxyl group in organic polymer particles having the hydroxyl group with a carboxylic anhydride. The organic polymer particles comprise a hydroxyl group originating from a 2,3-dihydroxypropyl group and a polyoxyethylene group.
1. Organic polymer particles, comprising:
a carboxyl group; and
a 2,3-dihydroxypropyl group;
wherein said organic polymer particles are separated and dispersed particles;
wherein the amount of the carboxyl group per the amount of solid components of said organic polymer particles is 5 to 100 μmol/g; and
wherein a dry coating film obtained from a water dispersion of said organic polymer particles has a contact angle with water of 60° or less.
2. The organic polymer particles as defined in claim 1 , further comprising superparamagnetic fine particles.
3. The organic polymer particles as defined in claim 2 , further comprising:
nuclear particles;
a magnetic material layer comprising the superparamagnetic fine particles, said magnetic material layer being provided in the outer layer of the nuclear particles; and
a polymer part having a carboxyl group and 2,3-dihydroxypropyl group, said polymer part being provided in the outer layer of the magnetic material layer.
4. The organic polymer particles as defined in claim 1 , wherein said carboxyl group is obtained by hydrolysis of a monomer (A) in which the carboxyl group is protected by a protecting group.
5. The organic polymer particles as defined in claim 4 , wherein said monomer (A) is (A-1) an ester monomer in which the carboxyl group of is protected by a tertiary alcohol.
6. The organic polymer particles as defined in claim 4 , wherein said monomer (A) is (A-2) a cyclic ester monomer obtained by internal condensation of a monomer having a carboxyl group and a hydroxyl group in one molecule.
7. The organic polymer particles as defined in claim 4 , wherein said monomer (A) is (A-3) an acid anhydride of a monomer having a carboxyl group.
8. The organic polymer particles as defined in claim 1 , wherein a number average particle diameter of said organic particles is 1 to 10 μm.
9. A probe, comprising:
the organic polymer particles as defined in claim 1 being bound to said probe.
10. Organic polymer particles, comprising:
a carboxyl group; and
a 2,3-dihydroxypropyl group;
wherein said organic polymer particles comprise a polymer part which comprises an ester bond and a functional group having a carboxylic group on a surface of the organic polymer particles;
wherein the ester bond is obtained by reacting a hydroxyl group of the organic polymer particles with a carboxylic anhydride;
wherein said organic polymer particles are separated and dispersed particles;
wherein a dry coating film obtained from a water dispersion of said organic polymer particles has a contact angle with water of 60° or less;
wherein the amount of the carboxyl group per the amount of solid components of said organic polymer particles is 5 to 100 μmol/g.