Granted Patent
B2
US 8,192,973 · App. 11/592,711 · Granted Jun 5, 2012
Detection of mutations in a gene associated with resistance to viral infection, OAS1
Assignee:
Kineta Two, LLC
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Abstract
A method for detecting a mutation related to the gene encoding OAS1. This and other disclosed mutations correlate with resistance of humans to viral infection including hepatitis C. Also provided is a therapeutic agent consisting of a protein or polypeptide encoded by the mutated gene, or a polynucleotide encoding the protein or polypeptide. Inhibitors of human OAS1, including antisense oligonucleotides, methods, and compositions specific for human OAS1, are also provided.
Claims (1)
1. An isolated polypeptide consisting of the amino acid sequence of SEQ ID NO:48.
Assignments (3)
MERGER
Recorded Aug 23, 2011
From: IB SECURITYHOLDERS, LLC
To: KINETA TWO, LLC
Reel/Frame 026793/0931 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Apr 26, 2011
From: CUBIST PHARMACEUTICALS, INC.; ILLUMIGEN BIOSCIENCES, INC.
To: IB SECURITYHOLDERS, LLC
Reel/Frame 026182/0758 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 4, 2006
From: IADONATO, SHAWN P.; MAGNESS, CHARLES L.; ROSENBERG, GARY; SCHERER, CHRISTINA A.; GUILLAUDEUX, THIERRY
To: ILLUMIGEN BIOSCIENCES, INC.
Reel/Frame 018592/0133 →
Continuity (8)
Provisional Application
60513888
· Oct 23, 2003
Provisional Application
60542373
· Feb 6, 2004
Provisional Application
60554758
· Mar 19, 2004
Provisional Application
60560524
· Apr 8, 2004
Provisional Application
60578323
· Jun 9, 2004
Provisional Application
60605243
· Aug 26, 2004