IP Library › Granted Patent US 7,872,112
Granted Patent B2
US 7,872,112 · App. 11/595,990 · Granted Jan 18, 2011

Expression vector encoding apoptosis-specific eIF-5A

Assignee: Senesco Technologies, Inc.
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Quick Facts
Patent No.
US 7,872,112
App. No.
11/595,990
Granted
Jan 18, 2011
Kind
B2
Abstract

The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.

Claims (2)

1. An expression vector comprising a polynucleotide encoding an apoptosis-specific eIF-5A and a promoter sequence operably linked to the poynucleotide wherein the apoptosis-specific eIF-5A comprises SEQ ID NO:1.

2. The expression vector of claim 1 wherein the promoter comprises the human cytomegalovirus immediate-early promoter/enhancer.

Assignments (2)
RELEASE OF SECURITY INTEREST IN INTELLECTUAL PROPERTY Recorded Mar 25, 2010
From: YA GLOBAL INVESTMENTS, L.P.
To: SENESCO TECHNOLOGIES, INC.; SENESCO, INC.
Reel/Frame 024128/0676 →
SECURITY AGREEMENT Recorded Feb 5, 2008
From: SENESCO TECHNOLOGIES, INC.; SENESCO, INC.
To: YA GLOBAL INVESTMENTS, L.P.
Reel/Frame 020468/0001 →
Continuity (3)
Continuation 1014164700 · May 7, 2002
Continuation In Part 0990979600 · Jul 23, 2001
Related Publication 20070059831A1 · Mar 15, 2007