IP Library Granted Patent US 8,415,398
Granted Patent B2
US 8,415,398 · App. 11/605,551 · Granted Apr 9, 2013

Materials and methods for treating viral infections

Inventors: Hao Yi Liang (Guangzhou, CN); Francis Chi (Kowloon, HK); Qingfu Xu (Rochester, NY); Bill Piu Chan (Beijing, CN)
Assignee: Obio Pharmaceutical (H.K.) Limited
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Quick Facts
Patent No.
US 8,415,398
App. No.
11/605,551
Granted
Apr 9, 2013
Kind
B2
Abstract

The subject invention provides materials and methods for treating various health conditions, including the prevention and/or treatment of a viral infection. In a preferred embodiment, a cysteamine compound is administered to a subject to treat an influenza virus infection. More preferably, a cysteamine compound is administered to a subject to treat influenza A, influenza B, influenza C virus infections, including avian influenza virus subtypes (such as H5N1 avian influenza virus).

Claims (14)

1. A method for treating a viral influenza infection, wherein said method comprises diagnosing a subject with the viral influenza infection; and administering to the subject an effective amount of cysteamine or a salt thereof.

2. The method, according to claim 1 , wherein the subject is infected with at least one of the group consisting of influenza virus subtype H1N1, H1N2, H2N2, H3N2, H3N8, H5N1, H5N2, H5N3, H5N8, H5N9, H7N1, H7N2, H7N3, H7N4, H7N7, H9N2, and H10N7.

3. The method, according to claim 2 , wherein the influenza virus subtype(s) is selected from the group consisting of avian influenza viruses, Spanish influenza viruses. Asian influenza viruses, Hong Kong influenza viruses, swine influenza viruses, equine influenza viruses, canine influenza viruses, and influenza A, B, and C viruses.

4. The method according to claim 1 , which comprises administering at least 0.1 mg of the cysteamine, or salt thereof, to the subject daily.

5. The method, according to claim 4 , which comprises administering between 2 mg to 3,000 mg of the cysteamine, or salt thereof, daily.

6. The method, according to claim 1 , wherein said cysteamine salt is cysteamine hydrochloride.

7. The method, according to claim 1 , wherein said cysteamine, or salt thereof, is taken orally, parenterally, intravenously, intramuscularly, transdermally, via buccal route, subcutaneously, or via suppository.

8. A method for reducing the severity, intensity, or duration of symptoms associated with a viral influenza infection, wherein said method comprises diagnosing a subject with the viral influenza infection; and administering to the subject an effective amount of cysteamine, or salt thereof.

9. The method, according to claim 8 , wherein the subject is infected with at least one of the group consisting of influenza virus subtype H1N1, H1N2, H2N2, H3N2, H3N8, H5N1, H5N2, H5N3, H5N8, H5N9, H7N1, H7N2, H7N3, H7N4, H7N7, H9N2, and H10N7.

10. The method, according to claim 9 , wherein the influenza virus subtype(s) is selected from the group consisting of avian influenza viruses, Spanish influenza viruses, Asian influenza viruses, Hong Kong influenza viruses, swine influenza viruses, equine influenza viruses, canine influenza viruses, and influenza A, B, and C viruses.

11. The method, according to claim 8 , which comprises administering at least 0.1 mg of the cysteamine, or salt thereof, to the subject daily.

12. The method, according to claim 11 , which comprises administering between 2 mg to 3,000 mg of the cysteamine, or salt thereof, daily.

13. The method according to claim 8 , wherein the cysteamine salt is cysteamine hydrochloride.

14. The method, according to claim 8 , wherein said cysteamine, or salt thereof, is taken orally, parenterally, intravenously, intramuscularly, transdermally, via buccal route, subcutaneously, or via suppository.

Assignments (2)
CHANGE OF NAME Recorded Feb 12, 2010
From: OMEGA-BIOPHARMA (H.K.) LIMITED
To: OBIO PHARMACEUTICAL (H.K.) LIMITED
Reel/Frame 023930/0910 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 10, 2007
From: LIANG, HAO YI; CHI, FRANCIS; XU, QINGFU; CHAN, BILL PIU
To: OMEGA-BIOPHARMA (H.K.) LIMITED
Reel/Frame 018737/0235 →
Continuity (5)
Provisional Application 60740584 · Nov 28, 2005
Provisional Application 60810773 · Jun 2, 2006
Provisional Application 60818885 · Jul 6, 2006
Provisional Application 60847020 · Sep 25, 2006
Related Publication 20070135525A1 · Jun 14, 2007