Noninvasive measuring device for substance in blood via nail and a nail evaporation device

1. A device for optically measuring a test substance in blood by using a nail as an optical window which comprises:

(i) a nail plate evaporation device, which partly removes a nail plate by evaporating the nail plate for creating an optical window in the nail, which comprises (a) a light generator generating a coherent light, (b) an evaporation depth monitor having a light detector detecting fluorescence emitted from the nail plate and the dermis for monitoring evaporation depth of the nail plate, and a controller which processes the detected fluorescence to determine evaporation depth information of the nail plate for controlling the light generator;

(ii) an irradiator configured to apply light within a wavelength range for measuring absorption by the test substance through the optical window;

(iii) a detector configured to detect light diffused/reflected from or transmitted through the body of a subject;

(iv) a processor configured to process a signal obtained by the detector to convert the signal into a concentration of the test substance;

(v) a monitor configured to monitor a water content and a keratin content of the nail by using light within a wavelength range for measuring absorption by water in the nail and light within a wavelength range for measuring absorption by keratin in the nail to correct or eliminate optical characteristics of the nail plate in the detected light.

2. The device according to claim 1 , wherein the irradiator and the detector are contained in a probe, and light is applied by the irradiator through the nail into the body of the subject and light diffused/reflected from the body of the subject is detected by the detector through the nail.

3. The device according to claim 1 , wherein the irradiator applying light within a wavelength range for measuring absorption by the test substance to the nail applies light to capillary vessel of the nail bed portion.

4. The device according to claim 1 , wherein the irradiator applying light within a wavelength range for measuring absorption by the test substance to the nail applies near infrared light.

5. The device according to claim 4 , wherein the wavelength range of the light to be applied is 1 to 2.5 μm.

6. The device according to claim 1 , wherein the device is a blood glucose level measuring device.

7. The device according to claim 1 , wherein the device is used for measuring blood urea, creatinine, BUN, or CP (creatinine phosphokinase).

8. The device according to claim 1 , wherein the monitor uses light having a wavelength of 1 to 3 μm as the light within a wavelength range for measuring absorption by water in the nail and light having a wavelength of 1 to 2.5 μm as the light within a wavelength range for measuring absorption by keratin in the nail.

9. The device according to claim 1 , wherein the coherent light source is ultraviolet laser light or OPO.

10. The device according to claim 9 , wherein the ultraviolet laser light is ArF laser light.

11. The device according to claim 1 , wherein a pulse energy density of the coherent light from the light generator is not less than 10 mJ/cm 2 ·pulse.

12. The device according to claim 1 , wherein, in monitoring the evaporation depth of the nail plate, irradiation is performed with a fluence such that intensity of plume emission, which is simultaneously generated in a wavelength range of fluorescence generating during light irradiation for evaporation, is equal to or less than intensity of fluorescence emitted from the nail plate and/or the dermis.

13. The device according to claim 1 , further comprising a holder of a finger tip portion, which has the laser light irradiator and the light detector.