Agents for imaging soluble a-beta
Provided herein are agents that bind to soluble beta-amyloid. Also provided are in vivo and in vitro methods for detecting soluble beta-amyloid in a sample that may include brain tissue.
1. A compound of formula III
wherein X is oxygen, nitrogen, or sulfur;
R 1 is substituted or unsubstituted alkyl, hydroxy, amide, urea, or urethane; and
R 3 is halogen, formyl, C 1 -C 32 substituted or unsubstituted, branched or straight chain alkyl, cycloaliphatic, aryl, arylalkyl, or heteroaryl; and
a label selected from radioisotopes, paramagnetic particles, and optical particles.
2. The compound of claim 1 , wherein the label is a radioisotope selected from 3 H, 11 C, 14 C, 18 F, 32 P, 35 S, 123 I, 125 I, 131 I, 51 Cr, 36 Cl, 57 Co, 59 Fe, 75 Se, and 152 Eu.
3. The compound of claim 2 , wherein the wherein the label is a radioisotope selected from 3 H, 11 C, 14 C, 18 F, 32 P, 35 S, 123I, 125 I, 131 I, 36 Cl, and 75 Se.
4. The compound of claim 1 , wherein the label is a paramagnetic particle selected from 157 Gd, 55 Mn, 162 Dy, 52 Cr, and 56 Fe.
5. The compound of claim 1 , wherein the label is an optical particle.
6. A compound according to claim 1 , wherein R3 is selected from
7. A compound according to claim 1 , wherein formula III is selected from
8. The compound of claim 7 , wherein the label is a radioisotope selected from 3 H, 11 C, 14 C, 18 F, 32 P, 35 S, 123 I, 125 I, 131 I, 51 Cr, 36 Cl, 57 Co, 59 Fe, 75 Se, and 152 Eu.
9. The compound of claim 7 , wherein the wherein the label is a radioisotope selected from 3 H, 11 C, 14 C, 18 F, 32 P, 35 S, 123 I, 125 I, 131 I, 36 Cl, and 75 Se.
10. The compound of claim 7 , wherein the label is a paramagnetic particle selected from 157 Gd, 55 Mn, 162 Dy, 52 Cr, and 56 Fe.
11. The compound of claim 7 , wherein the label is an optical particle.