IP Library › Granted Patent US 8,377,712
Granted Patent B2
US 8,377,712 · App. 11/609,202 · Granted Feb 19, 2013

Compositions and methods for the detection of chemical warfare agents

Inventors: Karl J. Wallace (Hattiesburg, MS); Eric V. Anslyn (Austin, TX)
Assignee: Board of Regents, The University of Texas System
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Quick Facts
Patent No.
US 8,377,712
App. No.
11/609,202
Granted
Feb 19, 2013
Kind
B2
Abstract

Compositions for detection of chemical warfare agents that comprise oximate anion reactive sites and fluorophore cores. Methods for detecting a chemical warfare agents that comprise providing a detector molecule comprising an oximate anion reactive site and a fluorophore core and detecting fluorescence from the detector molecule. Methods for enhancing the reactivity of an oximate nucleophile that comprise introducing an oxime into an aprotic solvent and deprotonating the oxime to form the oximate nucleophile with a base that creates noncoordinating anions.

Claims (2)

1. A composition for detection of a chemical warfare agent comprising a compound represented by the following formula:

wherein X is a structure represented by

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 17, 2010
From: OFFICE OF TECHNOLOGY COMMERCIALIZATION THE UNIVERSITY OF TEXAS AT AUSTIN
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 025002/0559 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 29, 2007
From: ANSLYN, ERIC V.; WALLACE, KARL J.
To: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 019081/0801 →
Continuity (2)
Provisional Application 60748912 · Dec 9, 2005
Related Publication 20120122228A1 · May 17, 2012