Short-acting benzodiazepines
The present invention provides a compound of formula (I): wherein all variables are as defined herein, pharmaceutical formulations containing the same, processes for preparing the same and their use therapy.
1. Methyl 3-[4S-8-bromo-1-methyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazepine-4-yl]propanoate or a pharmaceutically acceptable salt of solvate thereof.
2. A pharmaceutical formulation comprising a pharmaceutically acceptable carrier and an effective amount of a compound of claim 1 .
3. A method of providing sedation or hypnosis, inducing anxiolysis, inducing muscle relaxation in a mammal or treating convulsions in a mammal which comprises administering to the mammal an effective amount of a compound of claim 1 .
4. The method of claim 3 wherein the mammal is in need of sedation.
5. The method of claim 3 wherein the mammal is in need of hypnosis.
6. The method of claim 3 wherein the mammal is in need of muscle relaxation.
7. The method of claim 3 wherein the mammal suffers from convulsions.