Isoquinoline aminopyrazole derivatives

1. A compound according to

wherein:

(a) R 1 is selected from the group consisting of: hydrogen, alkyl, and cycloalkyl;

(b) R 2 is hydrogen or alkyl;

(c) R 3 is selected from the group consisting of:

(1) unsubstituted alkyl,

(2) alkyl which is substituted one or two times with —C(O)O-alkyl, heteroaryl, phenyl, heterocyclyl or cycloalkyl,

(3) alkyl wherein one or more —CH 2 — groups are replaced by oxygen,

(4) aryl which is optionally substituted one or more times with halogen, alkyl, halogenated alkyl, halogenated alkoxy, cyano, —C(O)-alkyl, —NH—C(O)-alkyl, —C(O)OH, —C(O)O-alkyl, unsubstituted alkoxy, alkoxy substituted by heterocyclyl, or —NR 2 ,

(5) heteroaryl which is optionally substituted one or more times with alkyl,

(6) cycloalkyl, and

(7) heterocyclyl;

(d) R 3a is selected from the group consisting of: hydrogen, alkyl, and alkoxy;

(e) R 4 is selected from the group consisting of: hydrogen, alkyl, alkoxy, halogen, cyano, —C(O)NR 2 , —(CH 2 ) n —Y—R 7 , and Z-R 8 ;

(f) R 5 is selected from the group consisting of: hydrogen, alkyl, alkoxy, halogen, cyano, —C(O)NR 2 , —(CH 2 ) n —Y—R 7 , and Z-R 8 ; and R 6 is selected from the group consisting of: hydrogen, alkyl, alkoxy, halogen, and cyano; or alternatively, R 5 and R 6 form, together with the carbon atoms to which they are attached, a 5- or 6-membered heterocyclic ring;

(g) X is selected from the group consisting of: a single bond, —NR—, —O—, —S—, —C(O)—, and —C(O)NR—;

(h) Y is selected from the group consisting of: —O—, —NR—, —S—, —S(O) 2 NR—, —NRC(O)—, —NRC(O)O—, and —C(O)NR—;

(i) Z is selected from the group consisting of: —C(O)—, —O—, a single bond, and alkylene;

(j) R 7 is cycloalkyl; or alkyl, which is optionally substituted one or more times by alkoxy, hydroxyl, alkylsulfonyl, heterocyclyl or NR 2 ;

(k) R 8 is heterocyclyl;

(l) R is hydrogen or alkyl; and

(m) n is 0, 1, 2 or 3;

or a pharmaceutically-acceptable salt or ester thereof.

2. A compound according to claim 1 , wherein R 3 is selected from the group consisting of: unsubstituted alkyl, cycloalkyl, and heterocyclyl.

3. A compound according to claim 1 , wherein:

(a) R 3 is selected from the group consisting of: unsubstituted alkyl, cycloalkyl, and heterocyclyl; and

(b) X is a single bond or —O—.

4. A compound according to claim 1 , wherein:

(a) R 3 is unsubstituted alkyl or cycloalkyl; and

(b) X is a single bond or —O—.

5. A compound according to claim 1 , wherein R 3 is unsubstituted alkyl.

6. A compound according to claim 1 wherein:

(a) R 3 is unsubstituted alkyl; and

(b) X is a single bond or —O—.

7. A compound according to claim 1 , wherein:

(a) R 3 is unsubstituted alkyl; and

(b) X is a single bond.

8. A compound according to claim 1 selected from the group consisting of:

(1-Isopropyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Cyclopropyl-1H-pyrazol-3-yl)-(1-isopropyl-6,7-dimethoxy-isoquinolin-3-yl)-amine;

[1-Isopropyl-6-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropyl-6-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

1-Isopropyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid (3-methoxy-propyl)-amide;

1-{4-[1-Isopropyl-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carbonyl]-piperazin-1-yl}-ethanone; and

(1-Isopropyl-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

9. A compound according to claim 1 selected from the group consisting of:

(1-Isopropyl-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Ethyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(8-Isopropyl-2,3-dihydro-1,4-dioxa-7-aza-phenanthren-6-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropyl-6-morpholin-4-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropyl-6-(4-methyl-piperazin-1-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropyl-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

(1-Isobutyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

10. A compound according to claim 1 , wherein:

(a) R 3 is aryl which is optionally substituted one or more times with halogen, alkyl, halogenated alkyl, halogenated alkoxy, cyano, —C(O)-alkyl, —NH—C(O)-alkyl, —C(O)OH, —C(O)O-alkyl, unsubstituted alkoxy or alikoxy substituted by heterocyclyl or —NR 2 ; and

(b) X is a single bond.

11. A compound according to claim 1 selected from the group consisting of:

(5-Methyl-1H-pyrazol-3-yl)-(1-phenyl-isoquinolin-3-yl)-amine;

[1-(4-Fluoro-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

4-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

[1-(4-Methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-[1-(4-trifluoromethyl-phenyl)-isoquinolin-3-yl]-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-p-tolyl-isoquinolin-3-yl)-amine;

[1-(4-Chloro-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Chloro-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

3-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile.

12. A compound according to claim 1 selected from the group consisting of:

[1-(3-Methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-[1-(3-trifluoromethyl-phenyl)-isoquinolin-3-yl]-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-m-tolyl-isoquinolin-3-yl)-amine;

1-{3-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone;

1-{4-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone;

[1-(2-Fluoro-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2,4-Difluoro-phenyl)-6,7-dimethoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-naphthalen-2-yl-isoquinolin-3-yl)-amine; and

[1-(4-tert-Butyl-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

13. A compound according to claim 1 selected from the group consisting of:

[1-(2,4-Difluoro-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3,4-Difluoro-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3,4-Dimethoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

N-{4-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-acetamide;

(6-Methoxy-1-phenyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

[1-(4-Ethoxy-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(4-trifluoromethyl-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

(6-Methoxy-1-p-tolyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

14. A compound according to claim 1 selected from the group consisting of:

[1-(4-Chloro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Chloro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

3-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

[6-Methoxy-1-(3-methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(3-trifluoromethyl-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-m-tolyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

1-{3-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone;

[1-{4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone; and

[1-(2-Fluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

15. A compound according to claim 1 selected from the group consisting of:

[6-Methoxy-1-(2-methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-naphthalen-2-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-tert-Butyl-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2,4-Difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3,4-Difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3,4-Dimethoxy-phenyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

N-{4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-acetamide;

[1-(2-Fluoro-phenyl)-5-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[5-Methoxy-1-(3-methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

3-[5-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile.

16. A compound according to claim 1 selected from the group consisting of:

(5-Methoxy-1-phenyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Fluoro-phenyl)-7-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[7-Methoxy-1-(3-methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

3-[7-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

(7-Methoxy-1-phenyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2,4-Difluoro-phenyl)-5-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2,4-Difluoro-phenyl)-7-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Fluoro-phenyl)-6,7-dimethoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6,7-Dimethoxy-1-(3-methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

(6,7-Dimethoxy-1-phenyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

17. A compound according to claim 1 selected from the group consisting of:

[1-(2-Fluoro-phenyl)-5,6-dimethoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[5,6-Dimethoxy-1-(3-methoxy-phenyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5,6-Dimethoxy-1-phenyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Phenyl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[1-(2-Methoxy-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(1H-Pyrazol-3-yl)-[1-(4-trifluoromethyl-phenyl)-isoquinolin-3-yl]-amine;

[1-(3-Fluoro-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

3-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yl]-benzoic acid ethyl ester;

[1-(4-Fluoro-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine; and

[1-(3-Methoxy-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine.

18. A compound according to claim 1 selected from the group consisting of:

4-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yl]-benzoic acid;

[1-(2-Fluoro-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(3,4-Difluoro-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(2,4-Difluoro-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(1H-Pyrazol-3-yl)-[1-(3-trifluoromethyl-phenyl)-isoquinolin-3-yl]-amine;

(1-Naphthalen-2-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

3-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

(1H-Pyrazol-3-yl)-(1-p-tolyl-isoquinolin-3-yl)-amine;

(1H-Pyrazol-3-yl)-(1-m-tolyl-isoquinolin-3-yl)-amine; and

[1-(4-tert-Butyl-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine.

19. A compound according to claim 1 selected from the group consisting of:

1-{4-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone;

1-{3-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone;

[1-(4-Chloro-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(3,4-Dimethoxy-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(4-Ethoxy-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

4-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

N-{4-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-acetamide;

(6-Methoxy-1-phenyl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine; and

1-{3-[6-Methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone.

20. A compound according to claim 1 selected from the group consisting of:

1-{4-[6-Methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-ethanone;

[1-(2-Fluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(3-methoxy-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(4-trifluoromethyl-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(4-Chloro-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

3-[6-Methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

[6-Methoxy-1-(3-trifluoromethyl-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(2,4-Difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(3,4-Difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine; and

[1-(3,5-Difluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine.

21. A compound according to claim 1 selected from the group consisting of:

[6-Methoxy-1-(2-methoxy-phenyl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-p-tolyl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-naphthalen-2-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[1-(4-Ethoxy-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-m-tolyl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[1-(3,4-Dimethoxy-phenyl)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

N-{4-[6-Methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-acetamide;

(5-Methyl-1H-pyrazol-3-yl)-[6-(2-morpholin-4-yl-ethoxy)-1-phenyl-isoquinolin-3-yl]-amine; and

[1-(3-Methoxy-phenyl)-6-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

22. A compound according to claim 1 selected from the group consisting of:

[1-(2,4-Difluoro-phenyl)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-morpholin-4-yl-methanone;

1-(2,4-Difluoro-phenyl)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid (3-methoxy-propyl)-amide;

[1-(2,4-Difluoro-phenyl)-6-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

3-[5,6-Dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

3-[6,7-Dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-benzonitrile;

{6-Methoxy-1-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-isoquinolin-3-yl}-(5-methyl-1H-pyrazol-3-yl)-amine;

{5-Methoxy-1-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-isoquinolin-3-yl}-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-6-isopropoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

{1-[3-(2-Dimethylamino-ethoxy)-phenyl]-isoquinolin-3-yl}-(5-methyl-1H-pyrazol-3-yl)-amine.

23. A compounds according to claim 1 , wherein:

(a) R 3 is heteroaryl which is optionally substituted one or more times with alkyl; and

(b) X is a single bond.

24. A compound according to claim 1 selected from the group consisting of:

(6-Methoxy-1-pyridin-4-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-pyridin-3-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-[1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-thiophen-3-yl-isoquinolin-3-yl)-amine;

(1-Benzo[b]thiophen-3-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-pyridin-3-yl-isoquinolin-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-pyridin-4-yl-isoquinolin-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-[1-(1H-pyrazol-4-yl)-isoquinolin-3-yl]-amine; and

(5-Methyl-1H-pyrazol-3-yl)-[1-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-3-yl]-amine.

25. A compound according to claim 1 selected from the group consisting of:

[6-Methoxy-1-(1H-pyrazol-4-yl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-thiophen-3-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Benzo[b]thiophen-3-yl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

N-{4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-phenyl}-acetamide;

(6-Methoxy-1-pyridin-3-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-pyridin-4-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(1H-pyrazol-4-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

[5-Methoxy-1-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

26. A compound according to claim 1 selected from the group consisting of:

(5-Methoxy-1-pyridin-3-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methoxy-1-thiophen-3-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[7-Methoxy-1-(1-methyl-1H-pyrazol-4-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(7-Methoxy-1-pyridin-3-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(7-Methoxy-1-thiophen-3-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Benzo[b]thiophen-3-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine; and

(1H-Pyrazol-3-yl)-(1-thiophen-3-yl-isoquinolin-3-yl)-amine.

27. A compound according to claim 1 selected from the group consisting of:

(1H-Pyrazol-3-yl)-[1-(1H-pyrazol-4-yl)-isoquinolin-3-yl]-amine;

[1-(1-Methyl-1H-pyrazol-4-yl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(1H-Pyrazol-3-yl)-(1-pyridin-3-yl-isoquinolin-3-yl)-amine;

(1H-Pyrazol-3-yl)-(1-pyridin-4-yl-isoquinolin-3-yl)-amine;

(6-Methoxy-1-thiophen-3-yl-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(4-methyl-thiophen-3-yl)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine; and

(1-Benzo[b]thiophen-3-yl-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine.

28. A compounds according to claim 1 , wherein:

(a) R 3 is alkyl which is substituted one or two times with heteroaryl, phenyl, heterocyclyl or cycloalkyl; and

(b) X is a single bond.

29. A compound according to claim 1 selected from the group consisting of:

(6-Methoxy-1-piperidin-1-ylmethyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

1-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylmethyl]-piperidin-2-one;

3-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylmethyl]-oxazolidin-2-one;

(6-Methoxy-1-pyrazol-1-ylmethyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine; and

(1-Benzyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

30. A compounds according to claim 1 , wherein:

(a) R 3 is cycloalkyl; and

(b) X is a single bond.

31. A compound according to claim 1 selected from the group consisting of:

(1-Cyclopropyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Cyclohexyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine; and

(1-Cyclopentyl-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

32. A compounds according to claim 1 , wherein:

(a) R 3 is alkyl which is substituted one time with phenyl; and

(b) X is —NR—.

33. A compound according to claim 1 selected from the group consisting of:

N 1 -Benzyl-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine; and

N 3 -(5-Methyl-1H-pyrazol-3-yl)-N 1 -((R)-1-phenyl-ethyl)-isoquinoline-1,3-diamine.

34. A compounds according to claim 1 , wherein:

(a) R 3 is aryl which is optionally substituted one or more times with halogen, alkyl, halogenated alkyl, halogenated alkoxy, cyano, —C(O)-alkyl, —NH—C(O)-alkyl, —C(O)OH, —C(O)O-alkyl, unsubstituted alkoxy, alkoxy substituted by heterocyclyl, or —NR 2 ; and

(b) X is —NR—.

35. A compound according to claim 1 selected from the group consisting of:

4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylamino]-benzonitrile;

4-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylamino]-benzonitrile;

N 1 -(4-Bromo-phenyl)-6-methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(4-Chloro-phenyl)-6-methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(4-Fluoro-phenyl)-6-methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

4-[6,7-Dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylamino]-benzonitrile;

4-[5,6-Dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylamino]-benzonitrile;

N 1 -(4-Butoxy-phenyl)-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(4-Butoxy-phenyl)-6-methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(4-Butoxy-phenyl)-6-methoxy-N 3 -(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine; and

N 1 -(3,4-Dimethoxy-phenyl)-N 3 -(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine.

36. A compound according to claim 1 selected from the group consisting of:

N 1 -(3,5-Dimethoxy-phenyl)-N 3 -(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(3-Ethyl-phenyl)-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(3-Ethyl-phenyl)-6-methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(3-Chloro-phenyl)-N-3-(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(3-Chloro-phenyl)-6-methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

N 1 -(3-Ethyl-phenyl)-6-methoxy-N 3 -(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine;

4-[5-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylamino]-benzonitrile;

4-[7-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylamino]-benzonitrile;

N 3 -(5-Methyl-1H-pyrazol-3-yl)-N 1 -phenyl-isoquinoline-1,3-diamine; and

N 1 -(4-Butoxy-phenyl)-N 3 -(1H-pyrazol-3-yl)-isoquinoline-1,3-diamine.

37. A compounds according to claim 1 , wherein:

(a) R 3 is heteroaryl which is optionally substituted one or more times with alkyl; and

(b) X is —NR—.

38. A compound according to claim 1 selected from the group consisting of:

N 3 -(5-Methyl-1H-pyrazol-3-yl)-N 1 -pyridin-4-yl-isoquinoline-1,3-diamine;

6-Methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-N 1 -pyridin-4-yl-isoquinoline-1,3-diamine;

N 3 -(1H-Pyrazol-3-yl)-N 1 -pyridin-4-yl-isoquinoline-1,3-diamine;

6-Methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-N 1 -pyridin-2-yl-isoquinoline-1,3-diamine;

N 3 -(1H-Pyrazol-3-yl)-N 1 -pyridin-2-yl-isoquinoline-1,3-diamine;

N 3 -(5-Methyl-1H-pyrazol-3-yl)-N 1 -pyridin-3-yl-isoquinoline-1,3-diamine; and

6-Methoxy-N 3 -(5-methyl-1H-pyrazol-3-yl)-N 1 -pyridin-3-yl-isoquinoline-1,3-diamine.

39. A compounds according to claim 1 , wherein:

(a) R 3 is selected from the group consisting of:

(1) alkyl which is substituted one to two times with phenyl, heterocyclyl, or cycloalkyl; and

(2) alkyl wherein one or more —CH 2 — groups are replaced by oxygen; and

(b) X is —O—.

40. A compound according to claim 1 selected from the group consisting of:

(1-Benzyloxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

{-[2-(2-Ethoxy-ethoxy)-ethoxy]-isoquinolin-3-yl}-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-[1-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-amine;

(5-Methyl-1H-pyrazol-3-yl)-[1-(2-piperidin-1-yl-ethoxy)-isoquinolin-3-yl]-amine;

(1-Benzyloxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(2-piperidin-1-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

{-[2-(2-Ethoxy-ethoxy)-ethoxy]-6-methoxy-isoquinolin-3-yl}-(5-methyl-1H-pyrazol-3-yl)-amine.

41. A compound according to claim 1 selected from the group consisting of:

[6-Methoxy-1-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Methoxy-phenoxy)-5-methyl-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1,6,7-trimethoxy-isoquinolin-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1,5,6-trimethoxy-isoquinolin-3-yl)-amine;

(1-Benzyloxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

{1-[2-(2-Ethoxy-ethoxy)-ethoxy]-isoquinolin-3-yl}-(1H-pyrazol-3-yl)-amine;

(1-Benzyloxy-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine; and

(1-Cyclopropylmethoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

42. A compounds according to claim 1 , wherein:

(a) R 3 is unsubstituted alkyl; and

(b) X is —O—.

43. A compound according to claim 1 selected from the group consisting of:

(1-Methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isobutoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1,6-Dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isobutoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-5-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1,5-Dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine; and

(1-Isopropoxy-7-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

44. A compound according to claim 1 selected from the group consisting of:

(1,7-Dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Methoxy-5-methyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Ethoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-5,6-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

(1-Isobutoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

(1-Isobutoxy-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-6-methoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine; and

(5-Cyclopropyl-1H-pyrazol-3-yl)-(1-ethoxy-6,7-dimethoxy-isoquinolin-3-yl)-amine.

45. A compound according to claim 1 selected from the group consisting of:

(5-Cyclopropyl-1H-pyrazol-3-yl)-(1-isopropoxy-6,7-dimethoxy-isoquinolin-3-yl)-amine;

[1-Isopropoxy-6-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-6-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-5-methyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-7-methoxy-6-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-7-methoxy-6-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-7-methoxy-6-(tetrahydro-pyran-4-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

1-Isopropoxy-7-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid (3-methoxy-propyl)-amide;

[1-Isopropoxy-7-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-morpholin-4-yl-methanone; and

1-Isopropoxy-7-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid dimethylamide.

46. A compound according to claim 1 selected from the group consisting of:

(8-Isopropoxy-2,3-dihydro-1,4-dioxa-7-aza-phenanthren-6-yl)-(5-methyl-1H-pyrazol-3-yl]-amine;

[1,6-Diethoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1,6-Diisopropoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-7-(2-methoxy-ethoxy)-6-(tetrahydro-furan-3-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

3-[1-Isopropoxy-7-(2-methoxy-ethoxy)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yloxy]-propane-1,2-diol;

[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-morpholin-4-yl-methanone;

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid dimethylamide;

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid (3-methoxy-propyl)-amide; and

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid (3-dimethylamino-propyl)-methyl-amide.

47. A compound according to claim 1 selected from the group consisting of:

[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-piperidin-1-yl-methanone;

[1-Isopropoxy-6-(4-methyl-piperazin-1-yl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-6-morpholin-4-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-6-piperidin-1-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-6-pyrrolidin-1-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-6-(4-methyl-piperazin-1-ylmethyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(S)-1-[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-ylmethyl]-pyrrolidine-2-carboxylic acid amide;

(1-Isopropoxy-6-methoxy-5-methyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(7-Fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine; and

(5-Cyclopropyl-1H-pyrazol-3-yl)-(7-fluoro-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-amine.

48. A compound according to claim 1 selected from the group consisting of:

[1-Isopropoxy-6-methoxy-7-(2-morpholin-4-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(7-Fluoro-1-isopropoxy-6-morpholin-4-yl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

1-[7-Fluoro-1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-pyrrolidin-2-one;

(5-Chloro-1-isopropoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Chloro-1,6-diisopropoxy-7-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Bromo-1-isopropoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid diethylamide;

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid isopropylamide;

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid cyclohexyl-methyl-amide; and

[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-(4-methyl-piperazin-1-yl)-methanone.

49. A compound according to claim 1 selected from the group consisting of:

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid methyl-(2-piperidin-1-yl-ethyl)-amide;

1-{4-[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carbonyl]-piperazin-1-yl}-ethanone;

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid methyl-(3-piperidin-1-yl-propyl)-amide;

[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-(4-methanesulfonyl-piperazin-1-yl)-methanone;

1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-6-carboxylic acid methyl-(tetrahydro-pyran-2-ylmethyl)-amide;

(3,5-Dimethyl-piperazin-1-yl)-[1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-methanone;

[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-[4-(2-methoxy-ethyl)-piperazin-1-yl]-methanone;

[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-(4-methoxy-piperidin-1-yl)-methanone;

(4-Hydroxy-piperidin-1-yl)-[1-isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-methanone; and

[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-pyrrolidin-1-yl-methanone.

50. A compound according to claim 1 selected from the group consisting of:

(7-Bromo-1-isopropoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(7-Bromo-1-isopropoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-Isopropoxy-6,7-bis-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Isopropoxy-6,8-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

1-Isopropoxy-6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-7-carboxylic acid dimethylamide;

1-Isopropoxy-6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-7-carbonitrile;

[1-Isopropoxy-6-methoxy-7-(2-piperidin-1-yl-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

1-[1-Isopropoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-pyrrolidin-2-one.

51. A compounds according to claim 1 , wherein:

(a) R 3 is aryl which is optionally substituted one or more times with halogen, alkyl, halogenated alkyl, halogenated alkoxy, cyano, —C(O)-alkyl, —NH—C(O)-alkyl, —C(O)OH, —C(O)O-alkyl, unsubstituted alkoxy, alkoxy substituted by heterocyclyl, or —NR 2 ; and

(b) X is —O—.

52. A compound according to claim 1 selected from the group consisting of:

[1-(4-Methoxy-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-phenoxy-isoquinolin-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-p-tolyloxy-isoquinolin-3-yl)-amine;

4-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile;

[1-(4-Chloro-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-m-tolyloxy-isoquinolin-3-yl)-amine;

[1-(3-Fluoro-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Chloro-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

[1-(3-Methoxy-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

53. A compound according to claim 1 selected from the group consisting of:

(5-Methyl-1H-pyrazol-3-yl)-(1-o-tolyloxy-isoquinolin-3-yl)-amine;

[1-(2-Fluoro-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Chloro-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Methoxy-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

3-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile;

(5-Methyl-1H-pyrazol-3-yl)-[1-(3-trifluoromethyl-phenoxy)-isoquinolin-3-yl]-amine;

[6-Methoxy-1-(4-methoxy-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-phenoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

(6-Methoxy-1-p-tolyloxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

54. A compound according to claim 1 selected from the group consisting of:

4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile;

[1-(4-Chloro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-m-tolyloxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Chloro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(3-methoxy-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-o-tolyloxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Fluoro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Chloro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

[1-(4-Methoxy-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine.

55. A compound according to claim 1 selected from the group consisting of:

N-{4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide;

N-{4-[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide;

N-{4-[5-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide;

N-{4-[7-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide;

[5-Methoxy-1-(4-methoxy-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methoxy-1-phenoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-5-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methoxy-1-p-tolyloxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

4-[5-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile; and

[1-(4-Chloro-phenoxy)-5-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

56. A compound according to claim 1 selected from the group consisting of:

[7-Methoxy-1-(4-methoxy-phenoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(7-Methoxy-1-phenoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-7-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

N-{4-[6-Methoxy-3-(1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide;

4-[7-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile;

[1-(4-Chloro-phenoxy)-7-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1-phenoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-5-methyl-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(5-methyl-1-p-tolyloxy-isoquinolin-3-yl)-amine; and

[1-(4-Chloro-phenoxy)-5-methyl-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

57. A compound according to claim 1 selected from the group consisting of:

(6,7-Dimethoxy-1-phenoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-6,7-dimethoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

N-{4-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide;

N-{4-[6,7-Dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide;

(5,6-Dimethoxy-1-phenoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-5,6-dimethoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

4-[5,6-Dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile;

[1-(4-Chloro-phenoxy)-5,6-dimethoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

N-{4-[5,6-Dimethoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yloxy]-phenyl}-acetamide; and

(1H-Pyrazol-3-yl)-(1-m-tolyloxy-isoquinolin-3-yl)-amine.

58. A compound according to claim 1 selected from the group consisting of:

(1H-Pyrazol-3-yl)-(1-p-tolyloxy-isoquinolin-3-yl)-amine;

(1H-Pyrazol-3-yl)-(1-o-tolyloxy-isoquinolin-3-yl)-amine;

[1-(3-Methoxy-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(2-Methoxy-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(2-Fluoro-phenoxy)-isoquinolin-3-yl]-(H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

3-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile;

4-[3-(1H-Pyrazol-3-ylamino)-isoquinolin-1-yloxy]-benzonitrile;

[1-(4-Chloro-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine; and

[1-(3-Chloro-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine.

59. A compound according to claim 1 selected from the group consisting of:

[1-(2-Chloro-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(1-Phenoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

(6-Methoxy-1-phenoxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(2-Fluoro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine; and

(6-Methoxy-1-p-tolyloxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine.

60. A compound according to claim 1 selected from the group consisting of:

(6-Methoxy-1-m-tolyloxy-isoquinolin-3-yl)-(1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(4-methoxy-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(3-methoxy-phenoxy)-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(4-Chloro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(3-Chloro-phenoxy)-6-methoxy-isoquinolin-3-yl]-(1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenoxy)-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-6-yl]-morpholin-4-yl-methanone; and

[1-(4-Fluoro-phenoxy)-6,8-dimethoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

61. A compounds according to claim 1 , wherein R 3 is cycloalkyl and X is —O—.

62. A compound according to claim 1 selected from the group consisting of:

(1-Cyclohexyloxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Cyclohexyloxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Cyclopentyloxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Cyclobutoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(1-Cyclobutoxy-6,7-dimethoxy-isoquinolin-3-yl)-(5-cyclopropyl-1H-pyrazol-3-yl)-amine;

[1-Cyclobutoxy-6-methoxy-7-(2-methoxy-ethoxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

1-Cyclobutoxy-6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-7-carboxylic acid dimethylamide;

1-Cyclopentyloxy-6-methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-7-carboxylic acid dimethylamide; and

1-Cyclobutoxy-6-methoxy-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine.

63. A compounds according to claim 1 , wherein R 3 is heterocyclyl and X is —O—.

64. A compound according to claim 1 selected from the group consisting of:

{6,7-Dimethoxy-1-[(R)-(tetrahydro-furan-3-yl)oxy]-isoquinolin-3-yl}-(5-methyl-1H-pyrazol-3-yl)-amine;

{6,7-Dimethoxy-1-[(S)-(tetrahydro-furan-3-yl)oxy]-isoquinolin-3-yl}-(5-methyl-1H-pyrazol-3-yl)-amine;

[6,7-Dimethoxy-1-(tetrahydro-furan-3-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-7-(2-methoxy-ethoxy)-1-(tetrahydro-furan-3-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-7-(2-methoxy-ethoxy)-1-(oxetan-3-yloxy)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-1-(tetrahydro-furan-3-yloxy)-isoquinoline-7-carbonitrile.

65. A compounds according to claim 1 , wherein:

(a) R 3 is selected from the group consisting of:

(1) alkyl which is substituted one time with —C(O)O-alkyl; and

(2) aryl which is optionally substituted one or more times with halogen, alkyl or unsubstituted alkoxy; and

(b) X is —S—.

66. A compound according to claim 1 selected from the group consisting of:

(5-Methyl-1H-pyrazol-3-yl)-(1-phenylsulfanyl-isoquinolin-3-yl)-amine;

[1-(3-Methoxy-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[6-Methoxy-1-(3-methoxy-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Chloro-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Chloro-phenylsulfanyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Fluoro-phenylsulfanyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(4-Fluoro-phenylsulfanyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Fluoro-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

[1-(2-Fluoro-phenylsulfanyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine.

67. A compound according to claim 1 selected from the group consisting of:

(6-Methoxy-1-phenylsulfanyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-p-tolylsulfanyl-isoquinolin-3-yl)-amine;

(6-Methoxy-1-p-tolylsulfanyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

(5-Methyl-1H-pyrazol-3-yl)-(1-m-tolylsulfanyl-isoquinolin-3-yl)-amine;

(6-Methoxy-1-m-tolylsulfanyl-isoquinolin-3-yl)-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Chloro-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(3-Chloro-phenylsulfanyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Chloro-phenylsulfanyl)-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine;

[1-(2-Chloro-phenylsulfanyl)-6-methoxy-isoquinolin-3-yl]-(5-methyl-1H-pyrazol-3-yl)-amine; and

[3-(5-Methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-ylsulfanyl]-acetic acid ethyl ester.

68. A compounds according to claim 1 , wherein R 3 is heterocyclyl and X is —C(O)—.

69. A compound according to claim 1 selected from the group consisting of:

[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-morpholin-4-yl-methanone;

1-{4-[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carbonyl]-piperazin-1-yl}-ethanone; and

[6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinolin-1-yl]-piperidin-1-yl-methanone.

70. A compounds according to claim 1 , wherein:

(a) R 3 is selected from the group consisting of:

(1) unsubstituted alkyl,

(2) alkyl which is substituted one or two times with phenyl or cycloalkyl,

(3) aryl, or

(4) cycloalkyl; and

(b) X is —C(O)NR—.

71. A compounds according to claim 1 selected from the group consisting of:

6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid cyclopropylmethyl-amide;

6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid dimethylamide;

6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid phenylamide;

6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid cyclohexylamide;

6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid benzylamide; and

6-Methoxy-3-(5-methyl-1H-pyrazol-3-ylamino)-isoquinoline-1-carboxylic acid cyclopropylamide.

72. A process for the preparation of a compound according to claim 1 , comprising the step of:

reacting a compound of formula II:

wherein R 1 , R 2 , R 4 , R 5 and R 1 are defined according to formula I in claim 1 ;

with a compound of formula III:

wherein R 3 has the significance given above for formula I in claim 1 and X is a single bond, —NR—, —O— or —S—.

73. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 and a pharmaceutically acceptable carrier.

74. A method of treating cancer comprising administering to a person in need thereof a therapeutically effective amount of a compound of claim 1 wherein the cancer is colon cancer.