IP Library › Granted Patent US 7,837,997
Granted Patent B2
US 7,837,997 · App. 11/640,737 · Granted Nov 23, 2010

Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots

Assignees: Trustees of the University of Pennsylvania; University of Virginia Patent Foundation
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Quick Facts
Patent No.
US 7,837,997
App. No.
11/640,737
Granted
Nov 23, 2010
Kind
B2
Abstract

Compositions and methods for prevention and treatment of uncontrolled formation of intravascular fibrin clots are provided wherein fibrinolytic or anticoagulant drugs are biocompatibly coupled to red blood cell carriers.

Claims (2)

1. A composition comprising biotinylated plasminogen activator cross-linked monovalently to a biotinylated red blood cell carrier via streptavidin.

2. The composition according to claim 1 , wherein the plasminogen activator is uPA or tPA.

Assignments (2)
CONFIRMATORY LICENSE Recorded Nov 27, 2022
From: UNIVERSITY OF PENNSYLVANIA
To: NIH - DEITR
Reel/Frame 061883/0814 →
CONFIRMATORY LICENSE Recorded Apr 22, 2021
From: UNIVERSITY OF PENNSYLVANIA
To: NIH - DEITR
Reel/Frame 056008/0455 →
Continuity (5)
Continuation 1025351800 · Sep 23, 2002
Division 0945466600 · Dec 3, 1999
Continuation In Part PCTUS991054700 · May 12, 1999
Provisional Application 6008626200 · May 21, 1998
Related Publication 20080050389A1 · Feb 28, 2008