Compounds for the treatment of inflammatory disorders
View Patent ↗This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.
1. A compound selected from the group consisting of:
or a pharmaceutically acceptable salt, solvate, ester, or isomer thereof.
2. The compound claim 1 , selected from the group consisting of:
or a pharmaceutically acceptable salt, solvate, ester or isomer thereof.
3. The compound claim 2 , selected from the group consisting of:
or a pharmaceutically acceptable salt, or solvate thereof.
4. A pharmaceutical composition comprising at least one compound of claim 1 , or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, and at least one pharmaceutically acceptable carrier.
5. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
6. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
7. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
8. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
9. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
10. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
11. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
12. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
13. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
14. A compound of the formula
or a pharmaceutically acceptable salt or solvate thereof.
15. The compound claim 5 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
16. The compound claim 6 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
17. The compound claim 7 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
18. The compound claim 8 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
19. The compound claim 9 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
20. The compound claim 10 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
21. The compound claim 11 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
22. The compound claim 12 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
23. The compound claim 13 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
24. The compound claim 14 , wherein the pharmaceutically acceptable salt is a sodium or a hydrochloride salt.
25. A pharmaceutical composition comprising at least one compound of claim 5 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
26. A pharmaceutical composition comprising at least one compound of claim 6 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
27. A pharmaceutical composition comprising at least one compound of claim 7 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
28. A pharmaceutical composition comprising at least one compound of claim 8 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
29. A pharmaceutical composition comprising at least one compound of claim 9 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
30. A pharmaceutical composition comprising at least one compound of claim 10 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
31. A pharmaceutical composition comprising at least one compound of claim 11 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
32. A pharmaceutical composition comprising at least one compound of claim 12 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
33. A pharmaceutical composition comprising at least one compound of claim 13 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.
34. A pharmaceutical composition comprising at least one compound of claim 14 , or a pharmaceutically acceptable salt or solvate thereof, and at least one pharmaceutically acceptable carrier.