IP Library Granted Patent US 7,705,131
Granted Patent B2
US 7,705,131 · App. 11/654,074 · Granted Apr 27, 2010

Method for diagnosing selected adenocarcinomas

Assignee: University of South Florida
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Quick Facts
Patent No.
US 7,705,131
App. No.
11/654,074
Granted
Apr 27, 2010
Kind
B2
Abstract

A method for the early diagnosing of selected adenocarcinomas in a human comprising the steps of removing a bodily sample from the human, and assaying the bodily sample for elevated expression of a specific gene. The gene being assayed for in the bodily sample is the TGFB-4 gene (hereinafter referred to as the endometrial bleeding associated factor (ebaf) gene. The bodily sample can be tissue from a specific organ in the body, or a blood sample. Increased levels of ebaf in the sample relative to basal levels may be indicative of a mucinous adenocarcinoma of the colon or ovaries, or an adenocarcinoma of the testis.

Claims (6)

1. An isolated antibody that specifically binds to the polypeptide of SEQ ID NO: 3.

2. The isolated antibody according to claim 1 , wherein said antibody is polyclonal.

3. The isolated antibody according to claim 1 , wherein said antibody is monoclonal.

4. A composition comprising a buffer and an antibody according to claim 1 .

5. The composition according to claim 4 , wherein said antibody is polyclonal.

6. The composition according to claim 4 , wherein said antibody is monoclonal.

Assignments (2)
CONFIRMATORY LICENSE Recorded Aug 9, 2011
From: UNIVERSITY OF SOUTH FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026719/0363 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 19, 2007
From: TABIBZADEH, SIAMAK; KOTHAPALLI, RAVI
To: UNIVERSITY OF SOUTH FLORIDA
Reel/Frame 019026/0860 →
Continuity (6)
Continuation 1020650800 · Jul 26, 2002
Division 0952683300 · Mar 16, 2000
Division 0934281900 · Jun 29, 1999
Continuation In Part 0891942100 · Aug 27, 1997
Provisional Application 6002580000 · Aug 27, 1996
Related Publication 20070172870A1 · Jul 26, 2007