Method and peptide for regulating cellular activity
Method and peptide for regulating cellular activity includes a panel of synthesized peptides that have biological effects on inhibiting or enhancing cellular activity. Selected peptides can be used as therapy to reduce and/or inhibit, or initiate and/or enhance, an inflammatory response in a subject.
1. A method of inhibiting Toll Like Receptor (TLR)-induced cytokine secretion comprising: administering to a subject in need thereof, an effective amount of a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 13; thereby inhibiting Toll Like Receptor (TLR)-induced cytokine secretion.
2. A method of inhibiting Toll Like Receptor (TLR)-induced cytokine secretion, comprising: administering to a subject in need thereof, an effective amount of a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 13 and a transducing sequence; thereby inhibiting Toll Like Receptor (TLR)-induced cytokine secretion.
3. The method of claim 2 , wherein the peptide is SEQ ID NO: 20.
4. A method of reducing or inhibiting Toll Like Receptor (TLR)-induced inflammation, comprising: administering to a subject in need thereof, an effective amount of:
a) a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 13, or
b) an effective amount of a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 13 and a transducing sequence; thereby reducing or inhibiting Toll Like Receptor (TLR)-induced inflammation.
5. The method of claim 4 , wherein an effective amount of a peptide consisting of the amino acid sequence set forth in SEQ ID NO: 13 and a transducing sequence is administered.
6. The method of claim 5 , wherein the peptide is SEQ ID NO: 20.
7. The method of claim 4 , wherein inflammation is caused by a bacteria.
8. The method of claim 7 , wherein the bacteria is Streptococcus pneumoniae.
9. The method of claim 5 , wherein the subject has otitis media.
10. The method of claim 1 , wherein: TLR is one or more of TLR 2, TLR3, TLR4, TLR5 and TLR9.
11. The method of claim 2 , wherein: TLR is one or more of TLR 2, TLR3, TLR4, TLR5 and TLR9.
12. The method of claim 4 , wherein: TLR is one or more of TLR 2, TLR3, TLR4, TLR5 and TLR9.
13. The method of claim 4 , wherein TLR is TLR2.
14. The method of claim 4 , wherein TLR is TLR3.
15. The method of claim 4 , wherein TLR is TLR4.
16. The method of claim 4 , wherein TLR is TLR5.
17. The method of claim 4 , wherein TLR is TLR9.