IP Library Granted Patent US 8,277,496
Granted Patent B2
US 8,277,496 · App. 11/657,188 · Granted Oct 2, 2012

Methods and devices for manipulating the thermoregulatory status of a mammal

Assignee: The Board of Trustees of the Leland Stanford Junior University
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Quick Facts
Patent No.
US 8,277,496
App. No.
11/657,188
Granted
Oct 2, 2012
Kind
B2
Abstract

Methods and devices for manipulating the thermoregulatory status of a mammal are provided. In the subject methods, thermal energy is transferred between the environment and both of the thoracic/abdominal core body and head of the mammal. In general, thermal energy transfer between thoracic/abdominal core body and the environment occurs under negative pressure conditions. The subject methods and devices can be used to increase the thoracic/abdominal core body temperature of a mammal, in which case thermal energy is introduced into the thoracic/abdominal core body of the mammal and removed from the head of the mammal or cold is merely applied thereto. The subject methods and devices can also be used to reduce the thoracic/abdominal core body temperature of a mammal, in which case thermal energy is removed from the thoracic/abdominal core body of the mammal and introduced into the head of the mammal or heat is merely applied thereto.

Claims (35)

1. A device for transferring energy with a portion of a mammal, the device comprising:

(a) a sealable enclosure for enclosing a portion of the mammal, wherein the sealable enclosure comprises a soft seal;

(b) a negative pressure production component configured to produce negative pressure conditions in the sealable enclosure; and

(c) an energy transfer element for transferring energy with the portion of the mammal when present in the sealable enclosure;

wherein the device is adapted to not cause local vasoconstriction at the surface of the mammal.

2. The device according to claim 1 , wherein the portion of the mammal is a limb or portion thereof.

3. The device according to claim 2 , wherein the limb is selected from the group consisting of an arm and a leg.

4. The device according to claim 1 , wherein the soft seal is compliant in its interface with a user, such that said seal may pass some air at the user/seal interface.

5. The device according to claim 4 , wherein the soft seal is a two-sided seal.

6. The device according to claim 1 , where the device is configured to extract thermal energy from the core body a mammal.

7. The device according to claim 1 , where the device is configured to introduce thermal energy into the core body a mammal.

8. The device according to claim 1 , wherein the device comprises a component configured to transfer energy with the head of a mammal.

9. The device according to claim 8 , wherein the device is configured to manipulate the thermal regulatory status of a mammal.

10. The device according to claim 1 , wherein the device comprises a temperature sensing element.

11. The device according to claim 10 , wherein the temperature sensing element is selected from the group consisting of thermocouples, thermosistors and microwave temperature sensors.

12. The device according to claim 1 , wherein the sealable enclosure is configured as sleeve, boot, shoe or glove.

13. The device according to claim 1 , wherein the device comprises a control element configured to actuate a component of the device in response to a detected change in temperature of a bodily compartment.

14. A method for increasing core body temperature of a mammal, said method comprising:

enclosing a portion of the mammal in a sealable enclosure, wherein the sealable enclosure comprises a soft seal;

contacting a surface of the enclosed portion of the mammal with a warm temperature medium under negative pressure conditions for a period of time sufficient to introduce thermal energy into the thoracic/abdominal core body of said mammal, and

applying a cold temperature medium to the head of the mammal in order to increase the thoracic/abdominal core body temperature of the mammal.

15. The method of claim 14 , wherein only the thoracic/abdominal core body temperature increases substantially.

16. The method of claim 14 , wherein both thoracic/abdominal and head core body temperatures increases substantially.

17. A method for decreasing core body temperature of a mammal, said method comprising:

enclosing a portion of the mammal in a sealable enclosure, wherein the sealable enclosure comprises a soft seal;

contacting a surface of the enclosed portion of the mammal with a cold temperature medium under negative pressure conditions for a period of time sufficient to introduce thermal energy into the thoracic/abdominal core body of the mammal, and

applying a warm temperature medium to the head of the mammal, wherein at least the thoracic/abdominal core body temperature of the mammal is decreased.

18. The method of claim 17 , wherein only the thoracic/abdominal core body temperature decreases substantially.

19. The method of claim 17 , wherein both thoracic/abdominal and head core body temperatures decreases substantially.

20. A method for manipulating the thermoregulatory status of a mammal, said method comprising:

enclosing a portion of the mammal in a sealable enclosure, wherein the sealable enclosure comprises a soft seal;

causing a transfer of thermal energy with the thoracic/abdominal core body of the mammal, and

causing a transfer of thermal energy with the head of the mammal, opposite the transfer with the thoracic/abdominal core to manipulate the thermoregulatory status of the mammal.

21. The method of claim 20 , wherein the transfers of thermal energies produce a compartmentalized thermoregulatory status.

22. The method of claim 20 , wherein the transfer of energy with the head is of an insignificant amount so as to produce an overall change in thermoregulatory status.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 7, 2012
From: BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 027824/0165 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 26, 2007
From: GRAHN, DENNIS A.; HELLER, H. CRAIG
To: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Reel/Frame 018931/0768 →
Continuity (5)
Continuation 10932344 · Aug 31, 2004
Continuation PCTUS0209772 · Mar 29, 2002
Continuation In Part 09878129 · Jun 7, 2001
Provisional Application 60210659 · Jun 9, 2000
Related Publication 20070123962A1 · May 31, 2007