Potassium channel inhibitors

1. A compound of the formula

or a pharmaceutically acceptable salt thereof, wherein

A is selected from the group consisting of

1) a phenyl ring, and

2) a pyridyl ring, wherein the point of attachment to the pyridyl ring is a carbon atom, wherein the phenyl ring and pyridyl ring are unsubstituted, mono-substituted with R 4 , disubstituted with groups independently selected from R 4 , trisubstituted with groups independently selected from R 4 , or tetrasubstituted with groups independently selected from R 4 , and wherein the N pyridyl ring atom is unsubstituted or substituted with oxo; and

C is selected from the group consisting of

1) an aryl ring, wherein any stable aryl ring atom is independently unsubstituted or substituted with a group selected from R 4 , and

2) C 1 —C 6 alkyl, wherein any stable atom is independently unsubstituted or substituted with a group selected from R 4 ;

B is a heteroaryl ring, wherein the point of attachment to the heteroaryl ring is a carbon atom, and wherein the heteroaryl ring is selected from the group consisting of pyridine and pyrimidine, wherein the heteroaryl ring is unsubstituted, mono-substituted with R 4 , disubstituted with groups independently selected from R 4 , trisubstituted with groups independently selected from R 4 , or tetrasubstituted with groups independently selected from R 4 , and wherein the N heteroaryl ring atom is unsubstituted or substituted with oxo;

X is OH;

Y is selected from the group consisting of

G, each time it occurs, is independently selected from the group consisting of H 2 and O;

Z is selected from the group consisting of C(R 6 ) 2 , NR 5 , NC(O)R 5 , NC(O)OR 5 , NC(O)N(R 5 ) 2 , NS(O) 1-2 R 5 , S(O) 0-2 , —N(R 5 )C(O)—, —C(R 5 )═C(R 6 )— and O;

R a , in each instance in which it appears, is independently selected from the group consisting of

1) hydrogen,

2) C 1 —C 6 alkyl,

3) halogen,

4) aryl,

5) heterocycle,

6) C 3 —C 10 cycloalkyl, and

7) OR 5 ,

said alkyl, aryl, heterocycle and cycloalkyl is unsubstituted or substituted with at least one substituent selected from R 6 ;

R 4 , in each instance in which it appears, is independently selected from the group consisting of

1) hydrogen,

2) halogen,

3) NO 2 ,

4) CN,

5) CR 4 ═C(R 5 ) 2 ,

6) C≡CR 5 ,

7) (CR a 2 ) n OR 5 ,

8) (CR a 2 ) n N(R 5 ) 2 ,

9) (CR a 2 ) n C(O)R 5 ,

10) (CR a 2 ) n C(O)OR 5 ,

11) (CR a 2 ) n R 5 ,

12) (CR a 2 ) n S(O) m R 5 ,

13) (CR a 2 ) n S(O) m N(R 5 ) 2 ,

14) OS(O) m R 5 ,

15) N(R 5 )C(O)R 5 ,

16) N(R 5 )S(O) m R 5 ,

17) (CR a 2 ) n N(R 6 )R 5 ,

18) (CR a 2 ) n N(R 5 )(CR a 2 ) n C(O)N(R 5 ) 2 ,

19) (CR a 2 ) n N(R 5 )(CR a 2 ) n C(O)OR 5 ,

20) N(R 5 )(CR a 2 ) n R 5 ,

21) N(R 5 )(CR a 2 ) n N(R 5 ) 2 , and

22) (CR a 2 ) n C(O)N(R 5 ) 2 ;

R 5 , in each instance in which it appears, is independently selected from the group consisting of

1) hydrogen,

2) unsubstituted or substituted C 1 —C 6 alkyl,

3) unsubstituted or substituted C 3 —C 10 cycloalkyl,

4) unsubstituted or substituted aryl,

5) unsubstituted or substituted heterocycle,

6) CF 3 ,

7) unsubstituted or substituted C 2 —C 6 alkenyl, and

8) unsubstituted or substituted C 2 —C 6 alkynyl, or in the case where R 5 is attached to a nitrogen atom that is disubstituted with R 5 , each R5 is independently selected from C 1 —C 6 alkyl, and the nitrogen atom together with each R 5 form a ring;

R 6 , in each instance in which it appears, is independently selected from the group consisting of

1) hydrogen,

2) unsubstituted or substituted C 1 —C 6 alkyl,

3) halogen,

4) OR 5 ,

5) CF 3 ,

6) unsubstituted or substituted aryl,

7) unsubstituted or substituted C 3 —C 10 cycloalkyl,

8) unsubstituted or substituted heterocycle,

9) S(O) m (R 5 ) 2 ,

10) C(O)OR 5 ,

11) C(O)R 5 ,

12) CN,

13) C(O)N(R 5 ) 2 ,

14) N(R 5 )C(O)R 5 ,

15) N(R 5 )C(O)OR 5 ,

16) N(R 5 )C(O)N(R 5 ) 2 ,

17) OC(O)N(R 5 ) 2 ,

18) S(O) m R 5 ,

19) OS(O) m R 5 ,

20) NO 2 ,

21) N(R 5 ) 2 ,

22) SC(O)R 5 ,

23) N(R 5 )S(O) m R 5 ,

R 7 is independently selected from the group consisting of

1) S(O) m N(R 5 ) 2 ,

2) C(O)OR 5 ,

3) C(O)R 5 ,

4) C(O)N(R 5 ) 2 , and

5) S(O) m R 5 ;

m is independently 0, 1 or 2;

n is independently 0, 1, 2, 3, 4, 5 or 6;

u is 0, 1 or 2; and

v is 0, 1 or 2 provided the compound is not

2. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein

B is a pyridyl ring, wherein the point of attachment to the pyridyl ring is a carbon atom, and wherein the pyridyl ring is unsubstituted, mono-substituted with R 4 , disubstituted with groups independently selected from R 4 , trisubstituted with groups independently selected from R 4 , or tetrasubstituted with groups independently selected from R 4 , and wherein the N atom is unsubstituted or substituted with oxo;

X is OH;

A is selected from the group consisting of

1) a phenyl ring, and

2) a pyridyl ring, wherein the point of attachment to the pyridyl ring is a carbon atom, wherein the phenyl ring and pyridyl ring are unsubstituted, mono-substituted with R 4 , disubstituted with groups independently selected from R 4 , trisubstituted with groups independently selected from R 4 , or tetrasubstituted with groups independently selected from R 4 , and wherein the N pyridyl ring atom is unsubstituted or substituted with oxo;

C is selected from the group consisting of

Y is selected from the group consisting of

3. A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of

(±)-2-Morpholin-4-yl-2-phenyl-1,1-dipyridin-3-yl-ethanol,

(±)-3-methyl-2-morpholin-4-yl-1,1-dipyridin-3-ylbutan-1-ol,

(±)-2-[(2-methoxyethyl)(methyl)amino]-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-phenyl-2-piperidin-1-yl-1,1-dipyridin-3-ylethanol,

(±)-2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-ylethanol,

(±)-tert-butyl 4-(2-hydroxy-1-phenyl-2,2-dipyridin-3-ylethyl)piperazine-1-carboxylate,

2-[(1S,4S)-2-oxa-5-azabicyclo[2.2.1]hept-5-yl]-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-(1,4-oxazepan-4-yl)-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-phenyl-1,1-dipyridin-3-yl-2-thiomorpholin-4-ylethanol,

(±)-2-(diethylamino)-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-(7-azabicyclo[2.2.1]hept-7-yl)-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-(3,3-difluoropyrrolidin-1-yl)-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-phenyl-1,1-dipyridin-3-yl-2-[2-(trifluoromethyl)pyrrolidin-1-yl]ethanol,

(±)-2-(2-isopropylpyrrolidin-1-yl)-2-phenyl-1,1-dipyridin-3-ylethanol,

(2R)-2-cyclopropyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-ylethanol,

(±)-2-[cyclobutyl(ethyl)amino]-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-[ethyl(2,2,2-trifluoroethyl)amino]-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-(3-fluoropyrrolidin-1-yl)-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-morpholin-4-yl-1,2-diphenyl-1-pyridin-2-yl-ethanol,

2-morpholin-4-yl-2-phenyl-1-pyridin-2-yl-1-pyridin-3-ylethanol,

(±)-2-phenyl-2-(phenylsulfonyl)-1,1-dipyridin-3-ylethanol,

(±)-2-(1,3-dimethyl-1H-1,2,4-triazol-5-yl)-1,1-dipyridin-3-yl-2-pyrrolidin-1-ylethanol,

(±)-1,2-diphenyl-2-(1H-pyrazol-1-yl)-1-pyridin-4-ylethanol,

(±)-3-(2-hydroxy-1-phenyl-2,2-dipyridin-3-ylethyl)-1,3-oxazolidin-2-one,

(±)-3-[2-hydroxy-1-(2-oxo-1,3-oxazolidin-3-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-1-[1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]-3-methylimidazolidin-2-one,

(±)-1-tert-butyl-3-[1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]imidazolidin-2-one,

(±)-3-(2-hydroxy-1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)-1,3-oxazolidin-2-one,

(±)-2-(1H-pyrazol-1-yl)-2-pyridin-2-yl-1,1-dipyridin-3-ylethanol,

(±)-2-(1H-pyrazol-1-yl)-1,1,2-tripyridin-3-ylethanol,

(±)-1,1,2-tripyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethanol,

(±)-4-[2-hydroxy-2,2-dipyridin-3-yl-1-(2H-1,2,3-triazol-2-yl)ethyl]benzonitrile,

(±)-3-[2-hydroxy-2,2-dipyridin-3-yl-1-(1H-1,2,3-triazol-1-yl)ethyl]benzonitrile,

(±)-(1-benzyl-1H-pyrazol-5-yl)(dipyridin-3-yl)methanol,

(±)-1-[1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]pyridin-2(1H)-one,

(±)-1-[1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]pyrazin-2(1H)-one,

(±)-2-[1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]pyridazin-3(2H)-one,

(R)-1-(2-hydroxy-1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)pyridin-2(1H)-one,

(S)-1-(2-hydroxy-1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)pyridin-2(1H)-one,

(±)-3-(2-hydroxy-2,2-dipyridin-3-yl-1-pyrrolidin-1-ylethyl)benzonitrile,

(±)-2-(4-fluorophenyl)-1,1-dipyridin-3-yl-2-pyrrolidin-1-ylethanol,

(±)-2-(3-methoxyphenyl)-1,1-dipyridin-3-yl-2-pyrrolidin-1-ylethanol,

2-[(2r)-2-(methoxymethyl)pyrrolidin-1-yl]-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-2-(3-bromophenyl)-1,1-dipyridin-3-yl-2-pyrrolidin-1-ylethanol,

(±)-2-(3,3-difluoroazetidin-1-yl)-2-(4-fluorophenyl)-1,1-dipyridin-3-ylethanol,

(±)-2-(5-chloro-2-thienyl)-1,1-dipyridin-3-yl-2-pyrrolidin-1-ylethanol,

2-[(3R,4R)-3,4-difluoropyrrolidin-1-yl]-2-phenyl-1,1-dipyridin-3-ylethanol,

(±)-1-(2-hydroxy-1-phenyl-2,2-dipyridin-3-ylethyl)piperidin-3-ol,

2-(4-fluorophenyl)-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-1,1-dipyridin-3-ylethanol,

(±)-2-(cyclobutylamino)-2-(4-fluorophenyl)-1,1-dipyridin-3-ylethanol,

(±)-2-phenyl-1,1-dipyridin-3-yl-2-[(2,2,2-trifluoroethyl)-amino]ethanol,

2-(benzyloxy)-N-[(1R)-2-hydroxy-1-phenyl-2,2-dipyridin-3-ylethyl]acetamide,

N-[(1R)-1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]-3-pyridin-2-yl-1H-pyrazole-5-carboxamide,

N-[(1R)-1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]-4-phenylbutanamide,

benzyl[(1R)-1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]carbamate,

N-[(1R)-1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]-1-phenyl-1H-pyrazole-4-carboxamide,

(±)-2-phenyl-1,1-dipyridin-3-yl-2-(1H-pyrrol-1-yl)ethanol,

(±)-3-(2-hydroxy-1-morpholin-4-yl-2,2-dipyridin-3-ylethyl)benzonitrile,

(±)-3,3′-(1-fluoro-2-phenyl-2-pyrrolidin-1-ylethane-1,1-diyl)dipyridine,

(±)-1-[1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]azetidin-3-ol,

(±)-1-[1-(4-fluorophenyl)-2-hydroxy-2,2-dipyridin-3-ylethyl]azetidin-3-yl phenylcarbamate,

(±)-2-(3,3-difluoroazetidin-1-yl)-2-(4-fluorophenyl)-1-(1-oxidopyridin-3-yl)-1-pyridin-3-ylethanol,

(±)-4-[1-(6-methoxypyridin-2-yl)-2,2-dipyridin-3-ylethyl]morpholine,

(±)-N-[1-(4-fluorophenyl)-2-phenyl-2-pyridin-3-ylethyl]-2-methoxyacetamide,

(±)-4-[1-(4-fluorophenyl)-2-phenyl-2-pyridin-3-ylethyl]morpholine,

(±)-1-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]pyrrolidin-2-one,

(±)-4-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]morpholine,

(±)-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl](2,2,2-trifluoroethyl)amine,

(±)-4-[1-(3,4-dichlorophenyl)-2,2-dipyridin-3-ylethyl]morpholine,

(±)-4-(1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)morpholine,

(±)-3,3′-[2-(4-fluorophenyl)-2-pyrrolidin-1-ylethane-1,1-diyl]dipyridine,

(±)-4-[1-(4-fluorophenyl)-2-pyridin-2-yl-2-pyridin-3-ylethyl]morpholine,

(±)-4-[1-(3-chlorophenyl)-2,2-dipyridin-3-ylethyl]morpholine,

(±)-4-[1-(3,5-dichlorophenyl)-2,2-dipyridin-3-ylethyl]morpholine,

(±)-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl](3,3,3-trifluoropropyl)amine,

(±)-[1-(3-chlorophenyl)-2,2-dipyridin-3-ylethyl](2,2,2-trifluoroethyl)amine,

(±)-[1-(3,5-dichlorophenyl)-2,2-dipyridin-3-ylethyl](2,2,2-trifluoroethyl)amine,

(±)-[1-(3,4-dichlorophenyl)-2,2-dipyridin-3-ylethyl](2,2,2-trifluoroethyl)amine,

(±)-3,3′-[2-(1,1-dioxidoisothiazolidin-2-yl)-2-(4-fluorophenyl)ethane-1,1-diyl]dipyridine,

(±)-4-[1-(6-methoxypyridin-2-yl)-2-phenyl-2-pyridin-2-ylethyl]morpholine,

(±)-4-[1-(6-bromopyridin-2-yl)-2,2-dipyridin-3-ylethyl]morpholine,

(±)-6-(1-morpholin-4-yl-2,2-dipyridin-3-ylethyl)pyridin-2-amine,

(±)-N-methyl-6-(1-morpholin-4-yl-2,2-dipyridin-3-ylethyl)pyridin-2-amine,

(±)-methyl[6-(1-morpholin-4-yl-2,2-dipyridin-3-ylethyl)pyridin-2-yl]carbamate,

(±)-[1-(3-bromophenyl)-2,2-dipyridin-3-ylethyl]{[1-(phenylsulfonyl)-1H-pyrrol-2-yl]methyl}amine,

(±)-methyl[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]prolinate,

(±)-3-{1-[2-(hydroxymethyl)pyrrolidin-1-yl]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N,N-dimethylprolinamide,

(±)-1-[1-(3-bromophenyl)-2,2-dipyridin-3-yethyl]-4-methylpiperazine-2,3-dione,

(±)-3-[1-(6-bromopyridin-2-yl)-2,2-dipyridin-3-ylethyl]-1,3-oxazolidin-2-one,

(±)-3-[1-(2-oxo-1,3-oxazolidin-3-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-benzyl (1,2,2-tripyridin-3-ylethyl)carbamate,

(±)-n-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-2-phenylcyclopropanecarboxamide,

(±)-3-(1-{[(1-phenyl-1h-pyrazol-4-yl)methyl]amino}-2,2-dipyridin-3-ylethyl)benzonitrile,

(R)-3-(1-morpholin-4-yl-2,2-dipyridin-3-ylethyl)benzonitrile,

(S)-3-(1-morpholin-4-yl-2,2-dipyridin-3-ylethyl)benzonitrile,

(±)-3-[2-(4-fluorophenyl)-1-pyridin-3-yl-2-(2,2,2-trifluoroethoxy)ethyl]pyridine,

(±)-3-[2-(4-fluorophenyl)-2-methoxy-1-pyridin-3-ylethyl]pyridine,

(±)-3-[2-(cyclopentyloxy)-2-(4-fluorophenyl)-1-pyridin-3-ylethyl]pyridine,

(±)-1-[1-(6-chloropyridin-2-yl)-2,2-dipyridin-3-ylethyl]pyridin-2(1H)-one,

(±)-1-(1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)pyridin-2(1H)-one,

(R)-1-(1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)pyridin-2(1H)-one,

(S)-1-(1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)pyridin-2(1H)-one,

(±)-2-[1-(1H-pyrazol-1-yl)-2,2-dipyridin-3-ylethyl]pyridine,

(±)-2-[2-(4-fluorophenyl)-1-(1H-pyrazol-1-yl)-2-pyridin-3-ylethyl]pyridine,

(±)-2-[2-(4-fluorophenyl)-1-(1H-pyrazol-1-yl)-2-pyridin-3-ylethyl]pyridine,

(±)-2-[1-(4-fluorophenyl)-2-(1H-imidazol-1-yl)-2-pyridin-3-ylethyl]pyridine,

(±)-1-(1,2,2-tripyridin-3-ylethyl)pyridin-2(1H)-one,

(±)-2-[2,2-dipyridin-3-yl-1-(1H-1,2,3-triazol-1-yl)ethyl]pyridine,

(±)-3-[2,2-dipyridin-3-yl-1-(1H-1,2,3-triazol-1-yl)ethyl]benzonitrile,

(±)-1-[1(2H)-yl)-2,2-dipyridin-3-ylethyl]pyridin-2(1H)-one,

(±)-1-phenyl-1,2-dipyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethanol,

(±)-1-phenyl-1-pyridin-2-yl-2-pyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethanol,

(±)-4-[2-hydroxy-2,2-dipyridin-3-yl-1-(1H-1,2,3-triazol-1-yl)ethyl]benzonitrile,

(±)-1-(2-hydroxy-2-phenyl-2-pyridin-2-yl-1-pyridin-3-ylethyl)pyridin-2(1H)-one,

(±)-1-(2-hydroxy-2-phenyl-1,2-dipyridin-3-ylethyl)pyridin-2(1H)-one,

(±)-1-(2-hydroxy-2-phenyl-2-pyridin-2-yl-1-pyridin-3-ylethyl)pyrazin-2(1H)-one,

(±)-2-(6-bromopyridin-3-yl)-1,1-dipyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethanol,

(±)-3-[1-hydroxy-2-(2-oxopyridin-1(2H)-yl)-2-pyridin-2-yl-1-pyridin-3-ylethyl]benzonitrile,

(±)-3-(2-hydroxy-1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)-1,3-oxazinan-2-one,

(±)-3-[2-(6-bromopyridin-3-yl)-1-hydroxy-1-pyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethyl]benzonitrile,

(±)-3-[1-hydroxy-1,2-dipyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethyl]benzonitrile,

(±)-3-[1-hydroxy-2-pyridin-2-yl-1-pyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethyl]benzonitrile,

(±)-3-(2-hydroxy-1-phenyl-2,2-dipyridin-3-ylethyl)-1,3-oxazinan-2-one,

(±)-3-[1-hydroxy-2-(2-oxo-1,3-oxazinan-3-yl)-2-pyridin-2-yl-1-pyridin-3-ylethyl]benzonitrile,

(S)-{1-[1-(3-bromophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl}ethanethioate,

(±)-3-[1-(2,4-dioxoimidazolidin-1-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-3-[1-(2-oxomorpholin-4-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-3-[1-(2-hydroxymorpholin-4-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N,N-bis(1-{1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]prolyl}pyrrolidin-2-yl)prolinamide,

(±)-3-(1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)-1,3-oxazolidin-2-one,

(±)-tert-butyl 2-{[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]amino}ethylcarbamate,

(±)-3-[1-(2-oxo-1,3-oxazinan-3-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-N-(2-{[1-(3-bromophenyl)-2,2-dipyridin-3-ylethyl]amino}ethyl)methanesulfonamide,

(±)-3-(1-morpholin-4-yl-2,2-dipyridin-3-ylethyl)phenol,

(±)-3-[1-(6-bromopyridin-2-yl)-2,2-dipyridin-3-ylethyl]-1,3-oxazinan-2-one,

(±)-N-(2-{[1-(3-bromophenyl)-2,2-dipyridin-3-ylethyl]amino}ethyl)-n′-phenylurea,

(±)-N-(tert-butyl)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]prolinamide,

(±)-1-[(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-piperidinylprolinamide,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N-cyclohexylprolinamide,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N-phenylprolinamide,

(±)-methyl 1-[1-(6-bromopyridin-2-yl)-2,2-dipyridin-3-ylethyl]prolinate,

(±)-3-(1-{[(1-phenyl-1H-pyrazol-4-yl)methyl]amino}-2,2-dipyridin-3-ylethyl)benzonitrile,

(±)-methyl 1-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]prolinate,

(±)-methyl 1-[1-(6-aminopyridin-2-yl)-2,2-dipyridin-3-ylethyl]prolinate,

(±)-N-{1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl}-N-methylmethanesulfonamide,

(±)-3-[1-(2-oxopyrrolidin-1-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl phenylcarbamate,

(±)-1-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]-N-methylprolinamide,

(±)-N-ethyl-1-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]prolinamide,

(±)-N-{1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl}-N-methylcyclopropanesulfonamide,

(±)-3-[1-(1,1-dioxidoisothiazolidin-2-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-3-[1-(4,5-dihydro-1,3-thiazol-2-ylamino)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-methyl 1-(1-pyridin-2-yl-2,2-dipyridin-3-ylethyl)prolinate,

(±)-N-butyl-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]prolinamide,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N-isobutylprolinamide,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N-cyclobutylprolinamide,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N-cyclopentylprolinamide,

(±)-1-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]-N-pyridin-2-ylprolinamide,

(±)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]-N-[4-(trifluoromethyl)pyridin-2-yl]prolinamide,

(±)-N-(5-chloropyridin-2-yl)-1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]prolinamide,

(±)-4-[1-(3-bromophenyl)-2,2-dipyridin-3-ylethyl]morpholin-2-one,

(±)-N-{1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl}-N-cyclopropylmethanesulfonamide,

(±)-N-{1-[(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl}-N-ethylmethanesulfonamide,

(±)-N-{1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl}-N-ethylcyclopropanesulfonamide,

(±)-N-{1-[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]piperidin-4-yl}-N-methylethanesulfonamide,

(±)-methyl 1-[1-(3-cyanophenyl)-2-pyrazin-2-yl-2-pyridin-3-ylethyl]prolinate,

(±)-2-{1-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]pyrrolidin-2-yl}-1H-benzimidazole,

(±)-methyl 1-[1-(6-methoxypyridin-2-yl)-2,2-dipyridin-3-ylethyl]prolinate,

(±)-3-{1-[2-(1H-benzimidazol-2-yl)pyrrolidin-1-yl]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-N-(tert-butyl)-1-[1-(6-methoxypyridin-2-yl)-2,2-dipyridin-3-ylethyl]prolinamide,

(±)-2-{1-[1-(6-methoxypyridin-2-yl)-2,2-dipyridin-3-ylethyl]pyrrolidin-2-yl}-1H-benzimidazole,

(±)-tert-butyl 3-{[1-(3-cyanophenyl)-2,2-dipyridin-3-ylethyl]amino}piperidine-1-carboxylate,

(±)-{1-[2-(6-aminopyridin-2-yl)-1,2-dipyridin-3-ylethyl]pyrrolidin-2-yl}methanol,

(±)-3-(1-{[(4-phenyl-1,3-thiazol-2-yl)methyl]amino}-2,2-dipyridin-3-ylethyl)benzonitrile,

(±)-3-(1-{[(2-phenyl-1,3-thiazol-5-yl)methyl]amino}-2,2-dipyridin-3-ylethyl)benzonitrile,

(±)-3-{2,2-dipyridin-3-yl-1-[(pyridin-2-ylmethyl)amino]ethyl}benzonitrile,

(±)-3-(1-{[3-(4-methoxyphenoxy)benzyl]amino}-2,2-dipyridin-3-ylethyl)benzonitrile,

(±)-3-{2,2-dipyridin-3-yl-1-[(quinolin-3-ylmethyl)amino]ethyl}benzonitrile,

(±)-3-(1-{[4-(methylthio)benzyl]amino}-2,2-dipyridin-3-ylethyl)benzonitrile,

(±)-3-{1-[(2,2-dimethylpent-4-en-1-yl)amino]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-3-{1-[(4-propoxybenzyl)amino]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-3-{1-[(biphenyl-4-ylmethyl)amino]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-3-{1-[(1-benzothien-2-ylmethyl)amino]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-3-(2,2-dipyridin-3-yl-1-{[3-(trifluoromethyl)benzyl]amino}ethyl)benzonitrile,

(±)-3-{-[(4-cyanobenzyl)amino]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-3-{1-[2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-6-{1-[2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-2,2-dipyridin-3-ylethyl}pyridin-2-amine,

(±)-2-methoxy-6-{1-[2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-2,2-dipyridin-3-ylethyl}pyridine,

(±)-3-{2-(4-fluorophenyl)-2-[2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-1-pyridin-3-ylethyl}pyridine,

(±)-3-{1-[2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-2-pyrazin-2-yl-2-pyridin-3-ylethyl}benzonitrile,

(±)-3-{1-[2-(3-methyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]-2-pyrazin-2-yl-2-pyridin-3-ylethyl}benzonitrile,

(±)-3-[1-(3-hydroxypiperidin-1-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-4-[2-(6-aminopyridin-2-yl)-2-(3-hydroxypiperidin-1-yl)-1-pyridin-3-ylethyl]benzonitrile,

(±)-4-{2,2-dipyridin-3-yl-1-[(2,2,2-trifluoroethyl)amino]ethyl}benzonitrile,

(±)-4-{1-[(2-fluoroethyl)amino]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-4-{1-[(2,2-difluoroethyl)amino]-2,2-dipyridin-3-ylethyl}benzonitrile,

(±)-N-{1-[4-(methylthio)phenyl]-2,2-dipyridin-3-ylethyl}-N-(2,2,2-trifluoroethyl)amine,

(±)-N-{1-[4-(methylsulfonyl)phenyl]-2,2-dipyridin-3-ylethyl}-N-(2,2,2-trifluoroethyl)amine,

(±)-6-{2,2-dipyridin-3-yl-1-[(2,2,2-trifluoroethyl)amino]ethyl}pyridin-2-amine,

(±)-N-{1-[2-(methylthio)phenyl]-2,2-dipyridin-3-ylethyl}-N-(2,2,2-trifluoroethyl)amine,

(±)-N-{1-[2-(methylsulfonyl)phenyl]-2,2-dipyridin-3-ylethyl}-N-(2,2,2-trifluoroethyl)amine,

(±)-N-{1-[3-(methylthio)phenyl]-2,2-dipyridin-3-ylethyl}-N-(2,2,2-trifluoroethyl)amine,

(±)-N-{1-[3-(methylsulfonyl)phenyl]-2,2-dipyridin-3-ylethyl}-N-(2,2,2-trifluoroethyl)amine,

(±)-1-(2,3′-bipyridin-3-yl)-2,2-dipyridin-3-ylethanamine,

(±)-1-(2,3′-bipyridin-3-yl)-2,2-dipyridin-3-yl-N-(2,2,2-trifluoroethyl)ethanamine,

(±)-3-[1-(4-fluorophenyl)-2,2-dipyridin-3-ylethyl]-1,3-oxazolidin-2-one,

(±)-3-[1-(4-chlorophenyl)-2,2-dipyridin-3-ylethyl]-1,3-oxazolidin-2-one,

benzyl(±)-1-(4-chlorophenyl)-2,2-dipyridin-3-ylethylcarbamate,

(±)-4-[1-(2-oxo-1,3-oxazolidin-3-yl)-2,2-dipyridin-3-ylethyl]benzonitrile,

(±)-neopentyl 1-(4-chlorophenyl)-2,2-dipyridin-3-ylethylcarbamate,

(±)-N-{1-[2-(methylthio)pyrimidin-4-yl]-2,2-dipyridin-3-ylethyl}-n-(2,2,2-trifluoroethyl)amine,

(±)-4-{2-(2-fluoropyridin-3-yl)-2-pyridin-3-yl-1-[(2,2,2-trifluoroethyl)amino]ethyl}pyrimidin-2-amine,

(±)-6-{2-(4-fluorophenyl)-1-pyridin-3-yl-2-[(2,2,2-trifluoroethyl)amino]ethyl}pyridin-2-amine,

(±)-1-(2-morpholin-4-ylpyridin-3-yl)-2,2-dipyridin-3-ylethanol,

(±)-1-{2-[methyl(pyridin-3-yl)amino]pyridin-3-yl}-2,2-dipyridin-3-ylethanol,

(±)-3,3′,3″-[2-(1H-tetrazol-1-yl)ethane-1,1,2-triyl]tripyridine,

(±)-3-[2-pyridin-2-yl-1-pyridin-3-yl-2-(1H-1,2,3-triazol-1-yl)ethyl]benzonitrile,

(±)-2-[2,2-dipyridin-3-yl-1-(4H-1,2,4-triazol-4-yl)ethyl]pyridine,

(±)-4-{2-(4-chlorophenyl)-1-[2-(methylthio)pyrimidin-4-yl]-2-pyridin-3-ylethyl}morpholine,

(±)-4-[2-(4-chlorophenyl)-1-morpholin-4-yl-2-pyridin-3-ylethyl]pyrimidin-2-amine, and

(±)-6-[1-(3,3-difluoropyrrolidin-1-yl)-2,2-dipyridin-3-ylethyl]pyridin-2-amine.

4. A pharmaceutical formulation comprising a pharmaceutically acceptable carrier and the compound claim 1 or a pharmaceutically acceptable crystal form or hydrate thereof.

5. A pharmaceutical composition made by combining the compound of claim 1 and a pharmaceutically acceptable carrier.