Substituted aryloxy alkylamines and their use as monoamine neurotransmitter re-uptake inhibitors
This invention relates to novel substituted aryloxy alkylamines useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
1. A chemical compound which is
(±)-[(E)-3-(3,4-Dichlorophenoxy)-hex-4-enyl]-methylamine;
(±)-[(E)-3-(2,3-Dichlorophenoxy)-hex-4-enyl]-methylamine;
(±)-[(E)-3-(2,3-Difluorophenoxy)-hex-4-enyl]-methylamine;
(±)-[(E)-3-(4-Bromo-3-chlorophenoxy)-hex-4-enyl]-methylamine;
(±)-[(E)-3-(Naphthalen-1-yloxy)-hex-4-enyl]-methylamine;
(±)-[3-(2,3-Dichloro-phenoxy)-5-methyl-hex-4-enyl]-methylamine;
(±)-[3-(3,4-Dichloro-phenoxy)-5-methyl-hex-4-enyl]-methylamine;
(±)-[3-(4-Bromo-3-chloro-phenoxy)-5-methyl-hex-4-enyl]-methylamine;
(±)-[(E)-3-(3,4-Dichloro-phenoxy)-4-methyl-hex-4-enyl]-methylamine;
(±)-[(E)-2-(2,3-Dichloro-phenoxy)-pent-3-eny]-methylamine;
or a pharmaceutically acceptable salt thereof.
2. The chemical compound of claim 1 which is:
(±)-[3-(3,4-Dichloro-phenoxy)-5-methyl-hex-4-enyl]-methylamine
or a pharmaceutically acceptable salt thereof.
3. A method for treatment or alleviation of pain in a living animal body, which method comprises the step of administering to the living animal body in need thereof a therapeutically effective amount of (±)-[3-(3,4-Dichloro-phenoxy)-5-methyl-hex-4-enyl]-methylamine, any of its isomers or any mixture of its isomers, or a pharmaceutically acceptable salt thereof.
4. The method of claim 3 , wherein the living animal body is a human.