Oxime derivative and preparations thereof
The problem of the present invention is to provide a useful compound as a glucokinase activating agent, which is the oxime derivative of the formula [I]: wherein Ring A is aryl or heteroaryl; Q is cycloalkyl, heterocycle, alkyl or alkenyl; Ring T is heteroaryl or heterocycle; R 1 and R 2 are independently hydrogen atom, halogen atom, cycloalkylsulfonyl or the like; R 3 and R 4 are independently hydrogen atom, hydroxy, oxo, halogen atom or the like; R 5 is hydrogen atom, halogen atom, cyano, nitro, tetrazolyl or the like; or a pharmaceutically acceptable salt thereof.
1. A compound of the general formula:
wherein R 5A is a group of
or a pharmaceutically acceptable salt thereof.
2. A method for treating diabetes or a complication associated with diabetes, which comprises:
administering an effective dose of a compound of claim 1 or a pharmaceutically acceptable salt thereof to a patient in need thereof,
wherein said complication associated with diabetes is one or more complication selected from the group consisting of retinopathy, nephropathy, ischemic heart disease, arteriosclerosis and obesity.
3. A pharmaceutical composition comprising an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof as an active ingredient.