STAT3 phosphorylation inhibitor and notch1 expression inhibitor
The present invention relates to an agent for suppressing STAT3 phosphorylation and for suppressing Notch1 expression comprising as an active ingredient a compound represented by the following formula (1): wherein R 1 , R 2 and R 3 each independently represents a hydrogen atom or a methyl group; and X represents a linear or branched alkyl, alkylene or alkenylene group having 10 to 28 carbon atoms.
1. A method for treating cancer comprising administering an effective amount of a composition comprising as an active ingredient a compound which has an activity of improving STAT signal and Notch signal transduction system dysfunction and is represented by the following formula (I):
wherein R 1 , R 2 and R 3 each independently represents a hydrogen atom or a methyl group; and
X represents a linear or branched alkyl group,
in a mammal in need of such treatment.
2. A method for treating cancer comprising administering an effective amount of a composition comprising as an active ingredient a compound which has an activity of suppressing STAT3 phosphorylation and suppressing Notch1 expression and is represented by the following formula (1):
wherein R 1 , R 2 and R 3 each independently represents a hydrogen atom or a methyl group; and
X represents a linear or branched alkyl group,
in a mammal in need of such treatment.