Use of the transcription of the slug gene in evaluating the redisposition of a subject with cancer to develop metastatis
The invention relates to the Slug gene, the replication, transcription or expression products thereof and products related with the regulation of said Slug gene or with the regulation, elimination or degradation of the expression or translation products of same, which can be used in the identification, prevention or treatment of the spread or development of metastasis in cancer patients, such as a patient suffering from a cancer with cancer cells that express the Slug gene.
1. An in-vitro method for evaluating a predisposition of a human subject with epithelial cancer and/or breast cancer to develop metastasis which comprises:
(a) detecting, identifying and/or quantifying transcription of the Slug gene, in a sample of blood, or a derivative thereof, from said human subject, and
(b) evaluating the predisposition of the human subject to develop metastasis, wherein the presence of transcription products of the Slug gene in the blood or derivative thereof indicates the predisposition of said human subject to develop metastasis.
2. The method as claimed in claim 1 , characterized in that said detecting, identifying and/or quantifying is of a product of transcription selected from messenger RNA (mRNA) of the Slug gene, a fragment of said mRNA, complementary DNA (cDNA) to the RNA that encodes the product of transcription or expression of said Slug gene, a fragment of said cDNA, and mixtures thereof.
3. The method as claimed in claim 1 , characterized in that said human subject has a cancer whose cancerous cells are Slug+.
4. The method as claimed in claim 1 , characterized in that said epithelial and/or breast cancer is selected from the group consisting of epithelial lung cancer, epithelial gynecological tumors, epithelial ovarian cancer, breast carcinoma, or epithelial colon cancer.
5. The method as claimed in claim 3 , characterized in that said epithelial and/or breast cancer is selected from the group consisting of epithelial lung cancer, epithelial gynecological tumors, epithelial ovarian cancer, breast carcinoma, or epithelial colon cancer.