System and methods for optimized drug delivery and progression of diseased and normal cells
Systems for recommending an optimal treatment protocol for a specific individual are disclosed. The systems comprise generally a system model, a plurality of treatment protocols, a system model modifier, wherein said system model is modified by the system model modifier based on parameters specific to the individual; and a selector to select an optimal treatment protocol from said plurality of treatment protocols based on the modified system model. Systems embodying the above techniques but for a general patient are also disclosed. Systems for a general patient and an individual for various specific diseases are disclosed. Methods and computer program products embodying the above techniques are also disclosed.
1. A system for predicting a progression of cancer in individual patients comprising:
a cancer system model model;
a plurality of treatment protocols for treating cancer using drugs, including chemotherapy;
a system model modifier, wherein said cancer system model is modified by the system model modifier based on parameters specific to the individual; and
a predictor to predict the progression of cancer under the plurality of treatment protocols based on the modified system model.
2. The system of claim 1 wherein the system model further comprises:
a process model of cancer development; and
a treatment model that models the effects of treating cancer with drugs, including chemotherapy.
3. The system of claim 2 wherein said process model incorporates a distribution of cycling cells and quiescent cells.
4. The system of claim 2 where a tumor cell cycle is divided into at least four compartments G 1 , S, G 2 and M and a quiescent stage is denoted by G 0 , wherein each of said four compartments is further subdivided into sub-compartments and an ith sub-compartment representing cells of age in the corresponding compartment, wherein cells entering a compartment always enter a first sub-compartment of the compartment.
5. The system of claim 4 wherein the model traces development of cancer cells using a predetermined set of parameters by calculating a number of cells in each subcompartment using stepwise equations.
6. The system of claim 5 wherein a probability vector is used to determine a fraction of cells that leaves any subcompartment in a compartment to move to a first subcompartment of the next compartment.
7. The system of claim 5 where a set control functions uniquely determine an outcome of every single step, wherein said control functions depend on age of cells, state of a current population and associated environment.
8. The system of claim 5 wherein a tumor is modelled as a combination of a plurality of homogeneous group of cells, each of said homogeneous group of cells representing a similarly behaving group of cells distributed between all the compartments.
9. The system of claim 8 , wherein in each step, a number of cells in each sub-compartment of each compartment of each group is calculated according to factors including a previous state, parameters of tumor and drug concentration.
10. The system of claim 9 where spatial structure of the tumor is included in the model.
11. The system of claim 10 , wherein PK and PD, cytotoxic effects and cytostatic effects of anticancer drugs are incorporated into the model.
12. The system of claim 11 wherein a dose-limiting toxicity is incorporated into the model.
13. The system of claim 1 wherein, said parameters specific to the individual comprise parameters related to tumor dynamics, patient specific drug PK, and dynamics of dose-limiting host tissues.
14. The system of claim 13 , wherein said parameters related to tumor dynamics comprise age, weight, gender, percentage of healthy cells, desired length of treatment protocol, previous reaction to treatment, molecular markers, genetic markers, pathologic specifics and cytologic specifics.
15. A system for predicting a progression of cancer in a general patients comprising:
a cancer system model;
a plurality of treatment protocols for treating cancer using drugs, including chemotherapy;
a system model modifier, wherein said cancer system model is modified by the system model modifier based on parameters specific to the population; and
a predictor to predict the progression of cancer under the plurality of treatment protocols based on the modified system model.
16. The system of claim 15 wherein the system model further comprises:
a process model of cancer development; and
a treatment model that models the effects of treating cancer with drugs, including chemotherapy.
17. The system of claim 16 wherein said process model incorporates a distribution of cycling cells and quiescent cells.
18. The system of claim 16 where a tumor cell cycle is divided into at least four compartments G 1 , S, G 2 and M and a quiescent stage is denoted by G 0 , wherein each of said four compartments is further subdivided into sub-compartments and an ith sub-compartment representing cells of age I in the corresponding compartment, wherein cells entering a compartment always enter a first sub-compartment of the compartment.
19. The system of claim 18 wherein the model traces development of cancer cells using a predetermined set of parameters by calculating a number of cells in each subcompartment using stepwise equations.
20. The system of claim 19 wherein a probability vector is used to determine a fraction of cells that leaves any subcompartment in a compartment to move to a first subcompartment of the next compartment.
21. The system of claim 19 where a set control functions uniquely determine an outcome of every single step, wherein said control functions depend on age of cells, state of a current population and associated environment.
22. The system of claim 19 wherein a tumor is modelled as a combination of a plurality of homogeneous group of cells, each of said homogeneous group of cells representing a similarly behaving group of cells distributed between all the compartments.
23. The system of claim 22 , wherein in each step, a number of cells in each sub-compartment of each compartment of each group is calculated according to factors including a previous state, parameters of tumor and drug concentration.
24. The system of claim 23 where spatial structure of the tumor is included in the model.
25. The system of claim 24 , wherein PK and PD, cytotoxic effects and cytostatic effects of anticancer drugs are incorporated into the model.
26. The system of claim 25 wherein a dose-limiting toxicity is incorporated into the model.
27. A computer implemented method of predicting a progression of cancer in a general patient, said method comprising:
creating a cancer system model;
enumerating a plurality of treatment protocols for treating cancer using drugs, including chemotherapy;
modifying the model, wherein said cancer system model is modified based on parameters specific to the population; and
predicting the progression of cancer under plurality of treatment protocols based on the modified system model.
28. The method of claim 27 wherein the system model further comprises:
a process model of cancer development; and
a treatment model that models the effects of treating cancer with drugs, including chemotherapy.
29. The method of claim 28 wherein said process model incorporates a distribution of cycling cells and quiescent cells.
30. The method of claim 28 where a tumor cell cycle is divided into at least four compartments G 1 , S, G 2 and M and a quiescent stage is denoted by G 0 , wherein each of said four compartments is further subdivided into sub-compartments and an ith sub-compartment representing cells of age I in the corresponding compartment, wherein cells entering a compartment always enter a first sub-compartment of the compartment.
31. The method of claim 30 wherein the model traces development of cancer cells using a predetermined set of parameters by calculating a number of cells in each subcompartment using stepwise equations.
32. The method of claim 31 wherein a probability vector is used to determine a fraction of cells that leaves any subcompartment in a compartment to move to a first subcompartment of the next compartment.
33. The method of claim 31 where a set control functions uniquely determine an outcome of every single step, wherein said control functions depend on age of cells, state of a current population and associated environment.
34. The method of claim 31 wherein a tumor is modelled as a combination of a plurality of homogeneous group of cells, each of said homogeneous group of cells representing a similarly behaving group of cells distributed between all the compartments.
35. The method of claim 34 , wherein in each step, a number of cells in each sub-compartment of each compartment of each group is calculated according to factors including a previous state, parameters of tumor and drug concentration.
36. The method of claim 35 where spatial structure of the tumor is included in the model.
37. The method of claim 36 , wherein PK and PD, cytotoxic effects and cytostatic effects of anticancer drugs are incorporated into the model.
38. The method of claim 37 wherein a dose-limiting toxicity is incorporated into the model.