Dihydroxyphenyl isoindolymethanones
Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.
1. A compound chosen from the group consisting of:
or a salt or hydrate thereof.
2. (2,4-Dihydroxy-5-isopropyl-phenyl)-[5-(2-dimethylamino-ethoxy)-1,3-dihydro-isoindol-2-yl]-methanone
or a salt or hydrate thereof, according to claim 1 .
3. (2,4-Dihydroxy-5-isopropyl-phenyl)-[5-(4-methyl-piperazin-1-yl)-1,3-dihydro-isoindol-2-yl]-methanone
or a salt or hydrate thereof, according to claim 1 .
4. (2,4-Dihydroxy-5-isopropyl-phenyl)-[5-(4-hydroxy-1-methyl-piperidin-4-yl)-1,3-dihydro-isoindol-2-yl]-methanone
or a salt or hydrate thereof, according to claim 1 .
5. (2,4-Dihydroxy-5-isopropyl-phenyl)-[5-(4-methyl-piperazin-1-ylmethyl)-1,3-dihydro-isoindol-2-yl]-methanone
or a salt or hydrate thereof, according to claim 1 .
6. (2,3-Dihydroxy-5-isopropyl-phenyl)-[5-(1-methyl-piperidin-4-ylamino)-1,3-dihydro-isoindol-2-yl]-methanone
or a salt or hydrate thereof, according to claim 1 .
7. (2,4-Dihydroxy-5-isopropyl-phenyl)-[5-(piperazin-1-yl)-1,3-dihydro-isoindol-2-yl]-methanone
or a salt or hydrate thereof, according to claim 1 .
8. (2,4-Dihydroxy-5-isopropyl-phenyl)-(5-dimethylaminomethyl-1,3-dihydro-isoindol-2-yl)-methanone
or a salt or hydrate thereof, according to claim 1 .
9. A pharmaceutical composition comprising a compound, or a salt or hydrate thereof, according to claim 1 and a pharmaceutically acceptable carrier.
10. A pharmaceutical composition according to claim 9 wherein said pharmaceutically acceptable carrier is a carrier for intravenous or oral administration.