Magnetic particles comprising an organic polymer layer and method for producing the same
Magnetic particles comprising a group shown by the following formula (1): wherein R 1 and R 2 individually represent a hydroxyl group, a group shown by the following formula (2), or a group shown by the following formula (3), provided that R 1 and R 2 are not both hydrogen atoms, wherein R 3 represents an a linear, branched, or cyclic alkylene group having 2 to 6 carbon atoms or an arylene group, and wherein R 4 is a hydrogen atom or an alkyl group.
1. Magnetic particles, each comprising
a non-magnetic material nucleus;
a magnetic material layer on the non-magnetic material nucleus; and
an organic polymer layer on the magnetic material layer, wherein
the organic polymer layer comprises an organic polymer comprising a group shown by the following formula (1) and a 2,3-dihydroxypropyl group,
wherein R 1 and R 2 individually represent a hydroxyl group, a group shown by the following formula (2), or a group shown by the following formula (3), provided that R 1 and R 2 are not both hydroxyl groups,
wherein R 3 represents an a linear, branched, or cyclic alkylene group having 2 to 6 carbon atoms or an arylene group, and
wherein R 4 is a hydrogen atom or an alkyl group.
2. The magnetic particles as defined in claim 1 , wherein the organic polymer further comprises an epoxy group.
3. The magnetic particles as defined in claim 1 , wherein
the organic polymer layer comprises a first organic polymer layer and a second organic polymer layer which covers the first organic polymer layer; and
the second polymer layer comprises the group shown by the formula (1).
4. The magnetic particles as defined in claim 3 , wherein the second polymer layer further comprises the 2,3-dihydroxypropyl group.
5. The magnetic particles as defined in claim 3 , wherein the second polymer layer further comprises an epoxy group.
6. The magnetic particles as defined in claim 5 , wherein each of the magnetic particles has a biotin-bonded probe bonded to the organic polymer layer.
7. The magnetic particles as defined in claim 1 , wherein each of the magnetic particles has a substance having a biotin-bonding site immobilized on the organic polymer layer.
8. The magnetic particles as defined in claim 7 , wherein the substance having a biotin-bonding site is at least one compound selected from the group consisting of avidin, streptavidin, and their derivatives.
9. The magnetic particles as defined in claim 1 , wherein the magnetic material layer comprises superparamagnetic particles.
10. The magnetic particles as defined in claim 1 , wherein the magnetic material layer comprises iron oxide particles.
11. A method of using magnetic particles, the method comprising
providing the magnetic particles of claim 1 , where at least one of R1 and R2 of the organic polymer comprises the group shown by the formula (2); and
reacting a substance having a biotin-bonding site with the group shown by the formula (2).
12. The method as defined in claim 11 , wherein
the magnetic particles further comprise an epoxy group; and
the method further comprises reacting the substance having a biotin-bonding site with the epoxy group.
13. A method of using magnetic particles, the method comprising
providing the magnetic particles of claim 1 , where at least one of R1 and R2 of the organic polymer comprises the group shown by the formula (3); and
reacting a substance having a biotin-bonding site with the group shown by the formula (3).
14. The method as defined in claim 13 , wherein
the magnetic particles further comprise an epoxy group; and
the method further comprises reacting the substance having a biotin-bonding site with the epoxy group.