Herpes simplex virus vector
View Patent ↗The invention provides a herpes simplex virus vector comprising deletions in ICP4, ICP27, and UL55.
1. A herpes simplex virus (HSV) vector comprising deletions in only the ICP4, ICP27, and UL55 genes and optionally comprising a transgene.
2. The vector of claim 1 , comprising a transgene.
3. A viral stock comprising the vector of claim 1 or 2 .
4. A composition comprising the vector of claim 1 or 2 and a physiologically-acceptable carrier.
5. A herpes simplex virus (HSV) vector comprising deletions in the ICP4, ICP27, and UL55 genes, and which comprises an intact inverted terminal repeat (ITR).
6. The HSV vector of claim 5 , which is deficient for at least one additional HSV gene.
7. The vector of claim 6 , wherein the additional HSV gene is an immediate early, early or late HSV gene.
8. The vector of claim 7 , wherein the immediate early gene is selected from the group consisting of: ICP22, ICP47, and a combination thereof.
9. The vector of claim 5 , wherein the recombinant HSV is replication-deficient.
10. The vector of any of claims 5 - 9 , further comprising a transgene.
11. A viral stock comprising the vector of any of claims 5 - 9 .
12. A viral stock comprising the vector of claim 10 .
13. A composition comprising the vector of any of claims 5 - 9 and a physiologically-acceptable carrier.
14. A composition comprising the vector of claim 10 and a physiologically-acceptable carrier.