Methods for inhibiting tumor cell proliferation
The subject invention concerns methods for inhibition of STAT biological functions using platinum complexes.
1. A method for inhibiting a Stat3 transcription factor comprising contacting a cell expressing a Stat3 transcription factor with a platinum complex having the structure:
or a pharmaceutically-acceptable salt thereof.
2. The method according to claim 1 , wherein said sell is a tumor cell, cancer cell, or a transformed cell.
3. The method according to claim 1 , wherein said cell is a mammalian cell.
4. The method according to claim 3 , wherein said mammalian cell is a human cell, monkey cell, chimpanzee cell, ape cell, dog cell, cat cell, horse cell, cow cell, or pig cell.
5. The method according to claim 1 , wherein said platinum complex is encapsulated in a liposome moiety or said platinum complex comprises a protein or nucleic acid that targets delivery of the platinum complex to said cell.
6. A method of inhibiting the function and/or growth and/or replication of a cell that is aberrantly or constitutively expressing a STAT transcription factor, comprising contacting said cell with a platinum complex having the structure:
or a pharmaceutically-acceptable salt thereof.
7. The method according to claim 6 , wherein said cell is a tumor cell, cancer cell, or a transformed cell.
8. The method according to claim 6 , wherein said cell is a mammalian cell.
9. The method according to claim 8 , wherein said mammalian cell is a human cell, monkey cell, chimpanzee cell, ape cell, dog cell, cat cell, horse cell, cow cell, or pig cell.
10. The method according to claim 6 , wherein said platinum complex is encapsulated in a liposome moiety or said platinum complex comprises a protein or nucleic acid that targets delivery of the platinum complex to said cell.