Granted Patent
B2
US 8,232,266 · App. 11/708,767 · Granted Jul 31, 2012
Use of manzamine compounds in anti-cancer therapeutic regimens
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Abstract
Manzamine compounds have been discovered to decrease cell dissociation and cell migration associated with the metastatic potential of cancer cells and a restoration of cancer cell susceptibility to agents, such as TRAIL, which can induce apoptosis. Specifically, Manzamine A has a formerly unrecognized utility in both blocking tumor cell invasion and tumor metastasis as well in restoring cancer cell susceptibility to standard chemotherapeutic agents which induce apoptosis and, therefore, has utility in treating cancer.
Claims (1)
1. A method for treating pancreatic cancer and inhibiting metastasis of pancreatic cancer cells wherein said method comprises administering, to pancreatic cancer cells, an effective amount of manzamine A.
Assignments (5)
CONFIRMATORY LICENSE
Recorded Jan 28, 2021
From: FLORIDA ATLANTIC UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH -DIRECTOR DEITR
Reel/Frame 055145/0768 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jun 21, 2012
From: HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC.
To: FLORIDA ATLANTIC UNIVERSITY BOARD OF TRUSTEES
Reel/Frame 028419/0139 →
CONFIRMATORY LICENSE
Recorded Mar 19, 2010
From: FLORIDA ATLANTIC UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024107/0029 →
CONFIRMATORY LICENSE
Recorded Sep 24, 2009
From: FLORIDA ATLANTIC UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 023276/0543 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 11, 2007
From: GUZMAN, ESTHER A.; JOHNSON, JACOB D.; WRIGHT, AMY E.
To: HARBOR BRANCH OCEANOGRAPHIC INSTITUTION, INC.
Reel/Frame 019279/0252 →
Continuity (2)
Provisional Application
60775435
· Feb 22, 2006