IP Library › Granted Patent US 7,786,090
Granted Patent B2
US 7,786,090 · App. 11/713,302 · Granted Aug 31, 2010

Methods and compositions for treating and preventing neurologic disorders

Assignee: President and Fellows of Harvard College
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Quick Facts
Patent No.
US 7,786,090
App. No.
11/713,302
Granted
Aug 31, 2010
Kind
B2
Abstract

The present invention provides methods for treating or reducing neurologic disorders.

Claims (6)

1. A method of treating cerebral ischemic disease by administering directly to a neural cell of a mammal an RNA interfering molecule that specifically targets and reduces the level or activity of human prolyl isomerase Pin1.

2. The method of claim 1 , wherein said cerebral ischemic disease is stroke.

3. The method of claim 1 , wherein said neural cell is a granule neuron.

4. The method of claim 1 , wherein said mammal is further administered a second therapeutic regimen.

5. The method of claim 1 , wherein said RNA interfering molecule specificallytargets GAGACCTGGGTGCCTTCAGCA (SEQ ID NO: 1)in Pin 1 mRNA.

6. The method of claim 1 , wherein said RNA interfering molecule is administered intrathecally.

Assignments (3)
CONFIRMATORY LICENSE Recorded Jul 16, 2010
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 024694/0362 →
CONFIRMATORY LICENSE Recorded Jan 29, 2009
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 022171/0838 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 22, 2007
From: BONNI, AZAD M.; BECKER, ESTHER B.E.
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 019470/0345 →
Continuity (2)
Provisional Application 6077853600 · Mar 1, 2006
Related Publication 20070282017A1 · Dec 6, 2007