Indoles having anti-diabetic activity
View Patent ↗Indoles having aryloxyalkanoic acid substituents or arylalkanoic acid substituents are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.
1. A method of treating a disease, condition or disorder selected from the group consisting of (1) non-insulin dependent Type 2 diabetes mellitus (NIDDM), (2) hyperglycemia, (3) low glucose tolerance, (4) insulin resistance, (6) a lipid disorder, (7) dyslipidemia, (8) hyperlipidemia, (9) hypertriglyceridemia, (10) hypercholesterolemia, (11) low HDL levels, (12) high LDL levels, (13) atherosclerosis, comprising administering an effective amount of a compound selected from the group consisting of:
or a pharmaceutically acceptable salt or solvate thereof.
2. A method in accordance with claim 1 further comprising administering to a patient in need of such treatment a therapeutically effective amount of an HMG-CoA reductase inhibitor.
3. The method of claim 2 , wherein the HMG-CoA reductase inhibitor is a statin selected from the group consisting of lovastatin, simvastatin, pravastatin, fluvastatin, atorvastatin, itavastatin, ZD-4522, rivastatin, and rosuvastatin.
4. A method in accordance with claim 1 wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
5. A method in accordance with claim 1 wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
6. A method in accordance with claim 1 wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
7. A method in accordance with claim 1 wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
8. A method in accordance with claim 1 wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
9. A pharmaceutical composition comprising a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof in combination with a pharmaceutically acceptable carrier.
10. A phannaceutical composition in accordance with claim 9 wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
11. A pharmaceutical composition in accordance with claim 9 , wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
12. A pharmaceutical composition in accordance with claim 9 wherein the compound is of the formula;
or a pharmaceutically acceptable salt thereof.
13. A pharmaceutical composition in accordance with claim 9 wherein the compound is of the formula:
or a pharmaceutically acceptable salt thereof.
14. A pharmaceutical composition in accordance with claim 9 wherein the compound is of the formula
or a pharmaceutically acceptable salt thereof.