Nucleic acids encoding a G-protein coupled receptor involved in sensory transduction
View Patent ↗The invention provides isolated nucleic acid and amino acid sequences of sensory cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sensory cell specific G-protein coupled receptors.
1. An isolated nucleic acid encoding a sensory transduction G-protein coupled receptor, the receptor comprising greater than about 90% amino acid sequence identity to the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2, wherein the receptor specifically binds to a compound that modulates taste, wherein said compound specifically binds to a sensory transduction G-protein coupled receptor having the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2.
2. The nucleic acid of claim 1 , wherein the receptor comprising greater than about 95% amino acid sequence identity to the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2.
3. The nucleic acid of claim 1 , wherein the receptor has the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2.