Tetrahydropyridines with central nervous system activity
View Patent ↗Provided are novel tetrahydropyridine derivatives bearing substituents. These compounds can be used for alleviating the symptoms of CNS disorders.
1. A composition comprising a compound having the following structure (2):
its enantiomer, or racemic mixtures thereof; wherein R can be such that the R-bearing ring is mono-, di- or tri-substituted, and in which each substituent is independently selected from the group consisting of substituted or unsubstituted phenyls, bromine, and chlorine.
2. The composition as in claim 1 wherein R is a p-bromo.
3. The composition as in claim 1 wherein R is a p-chloro.
4. The composition as in claim 1 wherein R is an unsubstituted p-phenyl.
5. The composition as in claim 1 wherein R consists of chlorine substituents at positions 3 and 4.
6. A composition comprising 1) a compound having the threo-diastereomeric structure of following structure (2):
or a diastereomeric mixture of said threo-diastereomer and its erythro diastereomer; wherein R can be such that the R-bearing ring is mono-, di- or tri-substituted, and in which each substituent is independently selected from the group consisting of substituted or unsubstituted phenyls, bromine, and chlorine.
7. The composition as in claim 6 wherein R is a p-bromo.
8. The composition as in claim 6 wherein R is a p-chloro.
9. The composition as in claim 6 wherein R is an unsubstituted p-phenyl.
10. The composition as in claim 6 wherein R consists of chlorine substituents at positions 3 and 4.
11. A composition comprising a compound having the following structure:
its enantiomer, or racemic mixtures thereof.
12. A composition comprising a compound having the threo-diastereomeric structure of following structure:
or a diastereomeric mixture of said threo-diastereomer and its erythro diastereomer.