Heat shock protein 90 inhibitors

1. Compounds corresponding to Formula I:

wherein A is hydrogen, halogen, lower alkyl, lower alkoxy, aryl, aralyl, or allyl;

wherein B is hydroxy, amino, halogen, lower alkoxy, or aralkoxy;

wherein C is hydroxy, amino, or lower alkoxy;

wherein D is alkyl, oxygen, amino, sulfanyl, sulfenyl, or sulfonyl;

wherein E is halogen, hydroxy, lower alkoxy, amino, or allyl amine;

wherein F is hydroxy, halogen, thiol, lower alkoxy, amino or oxidized to form a ketone;

wherein G is amino, thiol, hydroxy, lower alkoxy, or oxidized to form a ketone;

wherein I is amino;

wherein J is carbonyl;

wherein M is alkyl or cycloalkyl;

wherein K is alkyl or cycloalkyl; and

wherein R is hydrogen or alkyl.

2. The compounds according to claim 1 ,

wherein A is halogen;

wherein B and C are both hydroxy;

wherein D is oxygen;

wherein E is lower alkoxy;

wherein F and G are both oxidized to form a quinone;

wherein K is alkyl;

wherein I is amino comprising —NH—;

wherein J is carbonyl; and

wherein M is lower alkyl.

3. The compounds according to claim 1 ,

wherein A is halogen;

wherein B and C are both hydroxy;

wherein D is oxygen;

wherein E is lower alkoxy;

wherein F and G are both hydroxy;

wherein I is amino comprising —NH—;

wherein J is carbonyl;

wherein K is alkyl; and

wherein M is lower alkyl.

4. The compounds according to claim 1 ,

wherein A is halogen;

wherein B and C are both hydroxy;

wherein D is oxygen;

wherein E, F, and G are all lower alkoxy;

wherein I is amino comprising —NH—;

wherein J is carbonyl;

wherein K is alkyl; and

wherein M is lower alkyl.

5. The compounds according to claim 1 ,

wherein A is halogen;

wherein B and C are both hydroxy;

wherein D is oxygen;

wherein E is allyl amine;

wherein F and G are both oxidized to form a quinone;

wherein I is amino comprising —NH—;

wherein J is carbonyl,

wherein K is alkyl; and

wherein M is lower alkyl.

6. The compounds according to claim 1 ,

wherein A is phenyl;

wherein B and C are both hydroxy;

wherein D is oxygen;

wherein E, F, and G are all lower alkoxy;

wherein I is amino comprising —NH—;

wherein J is carbonyl;

wherein K is alkyl; and

wherein M is lower alkyl.

7. The compounds according to claim 1 ,

wherein A is halogen;

wherein B is lower alkoxy;

wherein C is hydroxy;

wherein D is oxygen;

wherein E, F, and G are all lower alkoxy;

wherein I is amino comprising —NH—;

wherein J is carbonyl;

wherein K is alkyl; and

wherein M is lower alkyl.

8. The compounds according to claim 1 ,

wherein A is halogen;

wherein B and C are both hydroxy;

wherein D is oxygen;

wherein E, F, and G are all lower alkoxy;

wherein I is amino comprising the formula —NR 1 — and wherein R 1 is alkyl;

wherein J is carbonyl;

wherein K is alkyl; and

wherein M is lower alkyl.

9. The compounds according to claim 1 ,

wherein A is halogen;

wherein B and C are both hydroxy;

wherein D is oxygen;

wherein E, F, and G are all lower alkoxy;

wherein I is amino comprising —NH—;

wherein J is carbonyl;

wherein K is lower alkyl; and

wherein M is lower alkyl.

10. The compounds according to claim 1 wherein both G and F are oxidized to form a quinone.

11. The compounds according to claim 1 wherein B and C are both hydroxy.

12. The compounds according to claim 1 wherein A is halogen.

13. The compounds according to claim 1 wherein R is hydrogen.

14. The compounds according to claim 1 wherein G and F are both hydroxy.

15. The compounds according to claim 1 wherein E, F, and G are each lower alkoxy.

16. The compounds according to claim 1 wherein F and G are oxidized to form a quinone, and E is allyl amine.