5 HT receptor mediated neurogenesis
The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a 5HTR agent, optionally in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.
1. A method of treating depression in a subject or patient, the method consisting of administering buspirone in a synergistic combination with melatonin, wherein the combination is effective to produce an improvement in the subject or patient.
2. The method of claim 1 , wherein the depression is due to morphine, alcohol, or drug use by the subject or patient.
3. The method of claim 1 , wherein the combination of buspirone and melatonin is in a pharmaceutically acceptable formulation.