3-heteroaryl-3,5-dihydro-4-oxo-4
View Patent ↗The invention discloses and claims therapeutic uses of compounds of general formula (I) Wherein X, R 1 , R 2 and R 3 are as described herein. The invention further discloses processes for preparing them, and novel intermediates therefor.
1. A method of treating a disease in a patient, said disease selected from the group consisting of peripheral neuropathy, and Parkinson's disease, comprising administering to said patient an effective amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof:
in which
X represents a hydrogen or halogen atom,
R 1 represents a hydrogen atom or a (C 1 -C 4 )alkyl group,
R 2 and R 3 each independently of one another represent a hydrogen atom or a (C 1 -C 4 )alkyl group, or else R 2 and R 3 , together with the nitrogen atom bearing them, form a pyrrolidinyl, piperidinyl, morpholinyl or 4-(C 1 -C 4 )alkylpiperazinyl group, and Het represents a heteroaromatic group of pyridinyl, quinolinyl, isoquinolinyl, pyrimidinyl, pyrazinyl or pyridazinyl type which may carry one or more halogen atoms and/or one or more (C 1 -C 4 )alkyl and/or (C 1 -C 4 )alkoxy groups.
2. The method according to claim 1 , wherein X represents a halogen atom.
3. The method according to claim 1 , wherein R 1 represents a (C 1 -C 4 )alkyl.
4. The method according to claim 1 , wherein R 2 and R 3 , each independently of one another, represent a (C 1 -C 4 )alkyl group or else R 2 and R 3 , together with the nitrogen atom bearing them, form a pyrrolidinyl or 4-(C 1 -C 4 )alkylpiperazinyl group.
5. The method according to claim 1 , wherein Het represents a heteroaromatic group of pyridinyl type which may carry one or more halogen atoms and/or one or more (C 1 -C 4 )alkyl and/or (C 1 -C 4 )alkoxy groups.
6. The method according to claim 1 , wherein X represents a chlorine atom and R 1 represents a methyl group.
7. The method according to claim 1 , wherein the disease is peripheral neuropathy.
8. The method according to claim 1 , wherein the disease is Parkinson's disease.
9. The method according to claim 2 , wherein the disease is peripheral neuropathy.
10. The method according to claim 2 , wherein the disease is Parkinson's disease.
11. The method according to claim 3 , wherein the disease is peripheral neuropathy.
12. The method according to claim 3 , wherein the disease is Parkinson's disease.
13. The method according to claim 4 , wherein the disease is peripheral neuropathy.
14. The method according to claim 4 , wherein the disease is Parkinson's disease.
15. The method according to claim 5 , wherein the disease is peripheral neuropathy.
16. The method according to claim 5 , wherein the disease is Parkinson's disease.
17. The method according to claim 6 , wherein the disease is peripheral neuropathy.
18. The method according to claim 6 , wherein the disease is Parkinson's disease.