Nicotinic acetylcholine receptor ligands 101
Nicotinic acetylcholine receptor ligands of Formula I wherein X, n, R 1 and R 2 are as described in the specification, diastereoisomers, enantiomers, pharmaceutically-acceptable salts, methods of making, pharmaceutical compositions containing, and methods for using the same.
1. A compound that is (2R)-5′-[5-(morpholin-4-ylmethyl)-3-furyl]-3′H-Spiro[4-azabicyclo[2.2.2]octane-2,2′-furo[2,3-b]pyridine] or a pharmaceutically acceptable salt thereof.
2. A pharmaceutically acceptable salt according to claim 1 that is a hydrochloride, a hydrobromide, a formate, an acetate, a maleate, a benzoate, a tartrate, or a fumarate.
3. A pharmaceutical composition comprising a compound or a pharmaceutically acceptable salt thereof according to claim 1 and at least one pharmaceutically acceptable diluent, lubricant or carrier.
4. A pharmaceutical composition comprising a pharmaceutically acceptable salt according to claim 2 and at least one pharmaceutically acceptable diluent, lubricant or carrier.