Sulphur containing pyrazole derivatives as selective cannabinoid CB
The present invention relates to sulphur containing pyrazole derivatives, and their S-oxidized active metabolites, as selective cannabinoid CB 1 receptor antagonists having a high CB 1 /CB 2 receptor subtype selectivity, to methods for the preparation of these compounds, to novel intermediates useful for the synthesis of these pyrazole derivatives, to pharmaceutical compositions comprising one or more of these pyrazole derivatives as active ingredients, as well as to the use of these pharmaceutical compositions for the treatment of psychiatric and neurological disorders. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.
1. Compound of formula (I),
wherein:
R 1 represents H, Cl or Br,
R 2 represents Cl or Br,
X represents a sulphur atom, a sulfoxide (S═O) or a sulfone (SO 2 ) moiety,
Y represents a methyl or an ethyl group, and
n can have the value 1, 2 or 3,
or a tautomer, stereoisomer, prodrug or N-oxide thereof, or a pharmacologically acceptable salt of said compounds of formula (I), or a tautomer, stereoisomer, or N-oxide of any of the foregoing.
2. A compound according to claim 1 , wherein R 1 and R 2 represent Cl, Y represents a methyl group, and n is 1 or 2.
3. A compound according to claim 2 , wherein X is a sulphur atom.
4. A pharmaceutical composition comprising a pharmaceutically active amount of at least one compound according to claim 1 as an active ingredient, and at least one of a pharmaceutically acceptable carrier or pharmaceutically acceptable auxiliary substance.
5. A pharmaceutical composition according to claim 4 , further comprising at least one additional medicament.
6. A method for preparing a pharmaceutical composition according to claim 4 , comprising bringing a compound according to claim 1 into a form suitable for administration.
7. A method for preparing a pharmaceutical composition according to claim 5 , comprising bringing a compound according to claim 1 into a form suitable for administration.
8. A compound of formula (IV) for use in the synthesis of a compound of claim 1 ,
wherein:
R 1 represents H, Cl or Br,
R 2 represents Cl or Br,
X represents a sulphur atom, a sulfoxide (S═O) moiety or a sulfone (SO 2 ) moiety,
Y represents a methyl or an ethyl group, and
R 4 represents a hydrogen, lithium, potassium or sodium atom.
9. A compound of the formula (V) for use in the synthesis of a compound of claim 1 ,
wherein:
R 1 represents H, Cl or Br,
R 2 represents Cl or Br,
Y represents a methyl or an ethyl group,
R 3 represents a methyl, ethyl or propyl group, and
X represents a sulphur atom, a sulfoxide (S═O) moiety or a sulfone (SO 2 ) moiety.
10. A process for preparing a compound according to claim 1 , comprising:
successively reacting a 1-aryl-2-alkylsulfanyl-ethanone derivative of formula (VIII),
wherein:
R 2 represents Cl or Br, and
Y represents a methyl or an ethyl group,
with a oxalic ester derivative of formula (IX),
wherein:
R 3 represents a linear C 1-3 alkyl group, in the presence of a base, in an inert anhydrous organic solvent, and reacting the product thereof with an arylhydrazine derivative of formula (X),
wherein:
R 1 represents H, Cl, or Br, to yield an ester of formula (V),
wherein:
R 1 represents H, Cl, or Br, R 2 represents Cl or Br, R 3 represents a linear C 1-3 alkyl group; and Y represents a methyl or an ethyl group.
11. The process according to claim 10 , wherein the R 3 group of the oxalic ester derivative of formula (IX) is methyl, ethyl, or n-propyl.
12. The process according to claim 10 , wherein the base is sodium alkanoate (NaOR 3 ).
13. The process according to claim 10 , wherein the inert anhydrous organic solvent is methanol, ethanol, or propanol.